Article
Biochemistry & Molecular Biology
Mohamadreza Tavakoli, Marjan Mirhaj, Saeideh Salehi, Jaleh Varshosaz, Sheyda Labbaf, Atefeh Golshirazi, Nafise Kazemi, Vida Haghighi
Summary: The study demonstrates the fabrication of polyvinyl alcohol (PVA) core and gelatin (Gel) shell core-shell nanofibers containing advanced platelet-rich fibrin (A-PRF). These nanofibers exhibit high porosity, specific surface area, and hydrophilicity. They also possess superior mechanical properties and degradability. The release of growth factors promotes cell proliferation and adhesion, accelerating wound healing. In vivo studies confirm the effectiveness of these nanofiber dressings in full-thickness wound repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Xiang Zhang, Dan Yao, Weiyi Zhao, Rui Zhang, Bingran Yu, Guiping Ma, Yang Li, Daifeng Hao, Fu-Jian Xu
Summary: The study developed an engineered PRP dual-network hydrogel (DN gel) based on sodium alginate, which has improved gelling property and sustained release of growth factors, showing great potential for the next generation of PRP-based bioactive wound dressings.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Applied
Xiangyan Chen, Hongjin Li, Xiaoni Qiao, Tianze Jiang, Xue Fu, Yue He, Xia Zhao
Summary: Marine agarose oligosaccharides and silver nanoparticles combined with antimicrobial peptides form a novel composite nanomaterial, which shows significant promoting effects on wound healing with strong antimicrobial activities and good biocompatibility.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Jiao Zhang, Qian Luo, Qian Hu, Tiantian Zhang, Jingyu Shi, Li Kong, Dehao Fu, Conglian Yang, Zhiping Zhang
Summary: Delayed diabetic wound healing is a significant burden on society. This study developed an injectable hydrogel (DPLG) based on PRP and laponite to overcome the limitations of PRP gels. DPLG demonstrated excellent wound healing acceleration through promoting macrophage polarization and angiogenesis.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Nanoscience & Nanotechnology
Changchang Kong, Shijunyin Chen, Wenhao Ge, Yang Zhao, Xiaodong Xu, Shiming Wang, Jianfa Zhang
Summary: In this study, an antibacterial and anti-inflammatory wound dressing based on riclin and silver nanoparticles was developed. The results showed that the dressing had sustained release of silver nanoparticles, effectively suppressed pathogen growth, and had negligible toxicity to human cells. In addition, it promoted faster and smoother wound healing while reducing the expression of inflammatory mediators.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Sibusiso Alven, Buhle Buyana, Zizo Feketshane, Blessing Atim Aderibigbe
Summary: Nanofibrous scaffolds loaded with silver nanoparticles show promising biological and mechanical outcomes in wound healing, with good antibacterial and bioactive properties.
Article
Chemistry, Multidisciplinary
Ning Tang, Rongjun Zhang, Youbin Zheng, Jing Wang, Muhammad Khatib, Xue Jiang, Cheng Zhou, Rawan Omar, Walaa Saliba, Weiwei Wu, Miaomiao Yuan, Daxiang Cui, Hossam Haick
Summary: The study introduces a novel self-healing, antibacterial, and multifunctional wound dressing for sutureless wound closure and real-time monitoring. The dressing features high mechanical toughness, biocompatibility, and outstanding antibacterial activity, effectively inhibiting bacterial growth and accelerating healing. In vivo tests demonstrate that the dressing can help in wound closure and deposition of collagen, while the integrated sensor array provides real-time monitoring of temperature, pH, and glucose levels in the wound area. Ultimately, this multifunctional dressing would be valuable for personalized monitoring and treatment approaches in wound healing management.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Mengmeng Xie, Yanbo Zeng, Hang Wu, Shige Wang, Jiulong Zhao
Summary: A multifunctional hydrogel has been developed that can rapidly stop bleeding and has antibacterial properties, promoting wound healing and repair. The hydrogel has good water retention capacity and mimics the three-dimensional structure of the natural extracellular matrix, making it promising for applications in hemostasis and wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Priyadarshani Choudhary, Baskaran Ramalingam, Sujoy K. Das
Summary: Wound dressings with poor antibacterial properties, adhesion to the wound site, weak mechanical strength, and lack of porosity and flexibility lead to blood loss, delayed wound repair, and sometimes death. In this study, a multifunctional graphene-based nanobiocomposite wound dressing was developed, which demonstrated hydrophilic properties, good mechanical strength, antibacterial activity, non-toxicity to cells, and pro-angiogenic potential. In in-vivo studies using a rat model, the nanobiocomposite dressing significantly enhanced wound healing compared to commercially available dressings, achieving complete wound closure in 14 days. Overall, the CGAPL nanobiocomposite dressing offers a novel and efficient solution for faster wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Irina Popescu, Marieta Constantin, Gheorghe Solcan, Daniela Luminita Ichim, Delia Mihaela Rata, Loredana Horodincu, Carmen Solcan
Summary: In this study, a composite hydrogel based on chitosan (CS) and polyvinyl alcohol (PVA) embedding silver nanoparticles (AgNPs) with antibacterial properties and ibuprofen (Ib) as an anti-inflammatory agent was developed. The hydrogel displayed good mechanical properties, high swelling degree, sustained drug delivery, and showed strong antibacterial activity. In vivo experiments demonstrated that the hydrogel accelerated wound healing process by activating downstream cascades and supporting the healing process of inflammation and promoting cell migration and proliferation.
Article
Materials Science, Biomaterials
Marjan Mirhaj, Mohamadreza Tavakoli, Jaleh Varshosaz, Sheyda Labbaf, Farnoosh Jafarpour, Parvin Ahmaditabar, Saeideh Salehi, Nafise Kazemi
Summary: Nanofibrous structures have shown great potential for medical applications. In this study, a Polycaprolactone/Keratin/Platelet-rich fibrin (PCL/Kr/PRF) fibrous scaffold fabricated through electrospinning was evaluated for wound healing. The scaffold exhibited smaller fiber diameter, increased antibacterial activity, and accelerated wound healing process. This study suggests that PCL/Kr/PRF could be a suitable candidate for wound healing and skin regeneration.
BIOMATERIALS ADVANCES
(2022)
Article
Materials Science, Multidisciplinary
Armin Amirsadeghi, Arman Jafari, Seyyedeh-Sara Hashemi, Aboozar Kazemi, Younes Ghasemi, Amin Derakhshanfar, Mohammad-Ali Shahbazi, Seyyed Vahid Niknezhad
Summary: Novel sprayable antibacterial dressings were developed by in-situ formation of Ag-nanoparticles using Persian gum as a carbohydrate polymer. The dressings showed good sprayability, antibacterial activity, and biocompatibility, indicating high potential for wound repair.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Chennan Liu, Junhong Ling, Li-Ye Yang, Xiao-kun Ouyang, Nan Wang
Summary: The development of a new type of dressing to combat bacterial resistance is of great importance. A carbon nitride-polydopamine-silver complex (C3N4-PDA-Ag) was prepared using C3N4 and silver nanoparticles (Ag NPs) to achieve a synergistic antimicrobial effect. The C3N4-PDA-Ag complex was further modified with chitosan (CS) to form a C3N4-PDA-Ag@CS film. The results showed that the C3N4-PDA-Ag@CS film exhibited superior antibacterial activity and biocompatibility, and promoted wound healing in infected mice.
CARBOHYDRATE POLYMERS
(2023)
Article
Biophysics
Ting Wang, Wanwan Yi, Yu Zhang, Hang Wu, Hengwei Fan, Jiulong Zhao, Shige Wang
Summary: In recent years, the healing of chronic wounds has become a challenging problem in clinical practice. This study aimed to address the challenges in wound care by designing a dual-network hydrogel composed of sodium alginate and platelet-rich plasma. The hydrogel showed a three-dimensional network structure and exhibited the potential for cell proliferation and vascular regeneration. When applied to wound skin in rats, the hydrogel effectively promoted wound closure. Overall, this strategy offers a simple and feasible approach for overcoming the shortcomings of conventional wound dressings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Chuan Tang, Bing Zhao, Jiajun Zhu, Xuan Lu, Ge Jiang
Summary: A chitosan/sodium cellulose sulfate composite film incorporated with silver nanoparticles was developed for wound dressing. The composite film exhibited a porous structure, excellent antibacterial properties, and a good wound healing effect, indicating its potential application in wound dressing.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Oncology
Aleksandra Zielinska, Agnieszka Mazdziarz, Nabil Abdalla, Wlodzimierz Sawicki, Ewa Dmoch-Gajzlerska
Summary: The association between lichen sclerosus (LS) and human papilloma virus (HPV) infections remains unclear, but photodynamic therapy (PDT) may be a promising, effective, and safe method for the treatment of LS regardless of HPV infection. Patients with HPV-negative results had a longer mean remission period compared to those with positive HPV results.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Environmental Sciences
Cezary Wojtyla, Pawel Stanirowski, Pawel Gutaj, Michal Ciebiera, Andrzej Wojtyla
Summary: This study compared perinatal outcomes in diabetic and obese Polish women, finding that GDM was the most common type of glucose intolerance in both groups. There was a slight increase in induced deliveries for obese women, and a significant decrease in fetal birth weight. The risk of GDM was significantly higher in women over 35 years and those who were overweight.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Pawel Jan Stanirowski, Agata Majewska, Michal Lipa, Dorota Bomba-Opon, Miroslaw Wielgos
Summary: Ultrasound-derived measurements of fetal soft tissue, heart, liver and umbilical cord are significantly increased in women with gestational diabetes treated with insulin and type 1 diabetes mellitus. In addition to standard biometric measurements, parameters such as abdominal fat mass may be useful in the management of diabetes-complicated pregnancies.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Pawel Jan Stanirowski, Dariusz Szukiewicz, Agata Majewska, Mateusz Watroba, Michal Pyzlak, Dorota Bomba-Opon, Miroslaw Wielgos
Summary: This study evaluated the placental expression of glucose transporters in term pregnancies complicated by GDM and PGDM. It found a significant increase in GLUT-1 expression in PGDM patients, while no significant differences were observed in other GLUT isoforms. Positive correlations were noted between fetal birthweight and the expression of GLUT-1 in PGDM group and GLUT-12 in the control group.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Medicine, General & Internal
Magdalena Bizon, Danuta Maslinska, Wlodzimierz Sawicki
Summary: The study demonstrates that photodynamic therapy can effectively improve the symptoms and quality of life in patients with lichen sclerosus. The history of neoplastic disease may influence the effectiveness of photodynamic therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Agata Majewska, Pawel Stanirowski, Miroslaw Wielgos, Dorota Bomba-Opon
Summary: Hyperglycaemia in pregnancy, commonly diagnosed as gestational diabetes mellitus (GDM), may not always match the clinical manifestations of GDM. Misdiagnosis of maturity-onset diabetes of the young (MODY) as GDM is suspected in 1-2% of cases. Proper diagnosis is crucial as misdiagnosis of MODY increases complications for both mother and fetus. This literature review provides current knowledge on the diagnosis, treatment, and complications of the most common types of MODY in pregnancy.
CURRENT DIABETES REVIEWS
(2023)
Review
Medicine, General & Internal
Agata Majewska, Pawel Jan Stanirowski, Miroslaw Wielgos, Dorota Bomba-Opon
Summary: Gestational diabetes mellitus (GDM) is a common complication of pregnancy, affecting up to 14% of pregnant women. Continuous glucose monitoring (CGM) has been shown to be safe and effective in improving glycaemic control in GDM. However, more research is needed to analyze the impact of CGM on perinatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Anna Markowska, Anita Chudecka-Glaz, Kazimierz Pitynski, Wlodzimierz Baranowski, Janina Markowska, Wlodzimierz Sawicki
Summary: Endometrial cancer is becoming more common in highly developed countries and is also affecting young women who want to preserve their fertility. Conservative treatment options, such as medication and local treatment, can be considered for these women.
Review
Obstetrics & Gynecology
Anna Markowska, Wlodzimierz Sawicki, Jakub Zurawski, Joanna Fechner, Janina Markowska
Summary: Chemoresistance and metastasis are the main reasons for treatment failure in ovarian cancer. Ascites is involved in cancer cell movement and metastasis through various molecular factors and signaling pathways. The spread of cancer cells through lymphatic and bloodstream is a multi-stage process.
GINEKOLOGIA POLSKA
(2022)
Review
Environmental Sciences
Joanna Weronika Krol, Pawel Jan Stanirowski, Natalia Mazanowska, Agata Majewska, Miroslaw Wielgos, Dorota Bomba-Opon
Summary: Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions diagnosed in early childhood. The etiology of ASDs is said to be a combination of genetic predisposition and environmental impact. Epidural analgesia (ELA) is a commonly used method of pain relief during labor, but a study in 2020 suggested a potential link between its use and the risk of ASD development in newborns. However, a review of the literature indicates that there is no significant association between the use of ELA during labor and the risk of ASD.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Obstetrics & Gynecology
Izabela Pilarska, Magdalena Bizon, Wlodzimierz Sawicki
Summary: This meta-analysis study aimed to examine the impact of COVID-19 on the placenta. The results showed that SARS-CoV-2 infection led to pregnancy complications in pregnant women, including caesarean delivery, preterm delivery, fetal distress, premature rupture of the membranes, and stillbirth. The study also found that placental damage was associated with SARS-CoV-2 infection. Further research is needed to better understand how SARS-CoV-2 infection affects the placenta.
GINEKOLOGIA POLSKA
(2023)
Review
Medicine, General & Internal
Daria Salloum, Pawel Jan Stanirowski, Aleksandra Symonides, Pawel Krajewski, Dorota Bomba-Opon, Miroslaw Wielgos
Summary: Polyhydramnios is a rare complication of pregnancy, with various causes including maternal diabetes and foetal malformations. This paper reports a rare case caused by CNL, where an enlarged lymph node in the abdomen exerted mechanical pressure on the foetal gastrointestinal tract, leading to polyhydramnios.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Jacek J. Sznurkowski, Janusz Rys, Artur Kowalik, Agnieszka Zolciak-Siwinska, Lubomir Bodnar, Anita Chudecka-Glaz, Pawel Blecharz, Aleksandra Zielinska, Andrzej Marszalek, Mariusz Bidzinski, Wlodzimierz Sawicki
Summary: Due to the heterogeneous nature of endometrial carcinoma, the Polish Society of Gynecological Oncology (PSGO) has developed new guidelines to summarize the current evidence for diagnosis, treatment, and follow-up of the disease and to provide evidence-based recommendations for clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Monika Wrobel, Zielinska Zuzanna, Lukasz Oldak, Aleksandra Kalicka, Grzegorz Manka, Mariusz Kiecka, Robert Z. Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Piotr Pierzynski, Cezary Wojtyla, Michal Lipa, Damian Warzecha, Miroslaw Wielgos, Wlodzimierz Sawicki, Ewa Gorodkiewicz, Piotr Laudanski
Summary: This study evaluated the levels of circulating 20S proteasome and 20S immunoproteasome in plasma and peritoneal fluid of women with and without endometriosis. The results indicate that these markers are not useful in diagnosing the disease but suggest a potential role in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Agata Majewska, Pawel Jan Stanirowski, Jacek Tatur, Barbara Wojda, Iwona Radosz, Miroslaw Wielgos, Dorota Agata Bomba-Opon
Summary: This study aimed to assess the efficacy of flash glucose monitoring (FGM) in the management of gestational diabetes mellitus (GDM). The results showed that the FGM group significantly reduced fasting and postprandial glycaemia during the first 4 weeks following GDM diagnosis, and the incidence of fetal macrosomia was significantly lower in the FGM group compared to the control group.
ACTA DIABETOLOGICA
(2023)
