Journal
ORGANIC LETTERS
Volume 13, Issue 5, Pages 1056-1059Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol103103n
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Funding
- Cancer Research UK [C1252/A9196]
- Advantage West Midlands (AWM)
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Readily available C-acylated cycloalkanones undergo efficient Pd catalyzed ring closure/cross-coupling providing 7-substituted tetra-hydroxanthones in a single operation. One of the synthesized derivatives (depicted) is shown to selectively kill pancreatic cancer (PANC-1) cells under conditions of nutrient deprivation indicating that the tetrahydroxanthone is responsible, in part, for the antiausterity effects of the naturally occurring kigamicins.
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