Journal
ORGANIC LETTERS
Volume 14, Issue 1, Pages 58-61Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol202829u
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- Rennes Metropole
- Region Bretagne
- Universite de Rennes 1
- Ministere de la Recherche
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We report a TMSI-promoted Prins cyclization reaction with ketones as carbonyl partners to prepare polysubstituted chiral spirotetrahydropyrans. In the presence of racemic 2-methylcyclohexanone a dynamic kinetic resolution occurred affording one stereoisomer. The observed enantiospecificity has been rationalized by DFT calculation.
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