Journal
ORGANIC LETTERS
Volume 12, Issue 1, Pages 168-171Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol902568x
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Funding
- Engineering and Physical Sciences Research Council [EP/G007519/1] Funding Source: researchfish
- EPSRC [EP/G007519/1] Funding Source: UKRI
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Insertion of benzene rings into the amide bond using the reactive intermediate benzyne is described. Aromatic amides undergo smooth insertion when treated with O-triflatophenyl silane benzyne precursors, producing versatile aminobenzophenone products in good to excellent yield. The process is entirely metal-free and has been exemplified on the synthesis of biologically active acridones and acridines.
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