Article
Chemistry, Physical
Jordan L. Harper, Stephanie Felten, Ryan M. Stolley, Alexander S. Hegg, Paul H-Y Cheong, Janis Louie
Summary: The mechanistic investigation into the origins of regio- and chemoselectivities observed in iron/pyridine dialdimine (PDAI)-catalyzed intermolecular [2+2+2] cycloaddition reactions of terminal alkynes and cyanamides reveals the significant role of the hemilabile PDAI ligand in controlling the observed selectivity of the resultant products.
Article
Chemistry, Organic
Grant N. Shivers, F. Christopher Pigge
Summary: This experiment presents a straightforward method for the preparation of N-alkenyl-2-pyridones in one pot, utilizing easily available reagents. The reaction displays high diastereoselectivity and tolerance towards a variety of aldehyde reaction partners. Furthermore, the resulting pyridone products are versatile and can be further manipulated to form N-alkyl pyridones and polycyclic ring systems.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Wenxu Chang, Zongyang Li, Chenhui Yuan, Xinying Liu, Jiyao Feng, Sen Pang, Liusheng Duan, Zhenhua Zhang
Summary: A facile and efficient method for synthesizing highly substituted 2-aminopyridines has been developed in this study. The method involves in situ transformation of unstable vinyl carbodiimides using a one-pot approach. Novel highly substituted 3-functionalized 2-aminopyridines were obtained in good yields. Reaction mechanism studies suggested that Rh and potassium carbonate played crucial roles in the cyclization step.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Medicinal
Carlos Santiago, Bernabe Ortega-Tenezaca, Iratxe Barbolla, Brenda Fundora-Ortiz, Sonia Arrasate, Maria Auxiliadora Dea-Ayuela, Humberto Gonzalez-Diaz, Nuria Sotomayor, Esther Lete
Summary: In this study, the authors used the SOFT.PTML tool to pre-process a ChEMBL dataset of pre-clinical assays of anti-leishmanial compound candidates. They compared different ML algorithms and found that the IFPTML-LOGR model had excellent specificity and sensitivity values. They illustrated the use of the software with a practical case study and identified compounds with potential activity. They also performed a computational high-throughput screening and validated the accuracy of the model.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Chemistry, Multidisciplinary
Sajan C. Patel, Noah Z. Burns
Summary: In this study, a new method for the transformation of aryl azides into 2-aminopyridines using blue light and oxygen is reported. The conversion of benzene to pyridine is achieved by nitrogen insertion into the benzene ring followed by oxidative carbon extrusion.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Daniel L. Comins
Summary: A short and economical synthesis of various 2-methylaminopyidine amides (MAPA) from 2-bromopyridine has been developed using the catalytic Goldberg reaction. The method also provides a new preparation of 2-N-substituted aminopyridines.
Article
Biochemistry & Molecular Biology
Aymard Didier Tamafo Fouegue, Hilaire Tendongmo, Eric Sakue Ngankam, Rahman Abdoul Ntieche
Summary: This study investigated the adsorption behavior of 2-aminopyridine and 3-aminopyridine on the external surface of B12N12 and Al12N12 fullerene-like nanocages through theoretical analysis. The results showed that all FLN@X-AP states were spontaneously formed and that the boron nitride FLN strongly adsorbed the APs through B-N covalent interactions. Furthermore, the adsorption of APs significantly changed the HOMO-LUMO band gap of B12N12, enhancing its conductivity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Applied
Yu-ki Sugiyama, Masaki Amo, Kouta Ibe, Sentaro Okamoto
Summary: The reactivity of nitriles in a CoCl2-6H(2)O/dppe/Zn-catalyzed diyne-nitrile cycloaddition was studied. It was found that cyanamides are good substrates and result in the formation of 2-aminopyridines. Notably, N-unsubstituted cyanamide (H2N-CN) can react with 1,6-diynes to produce N-unsubstituted 2-aminopyridines, which cannot be obtained through other catalytic reactions and serve as versatile intermediates for further transformations.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Savio Cardoza, Pooja Yadav, Abhishek Ajmani, Parthasarathi Das, Vibha Tandon
Summary: There is a continuous demand for new inhibitors of HIV-1 Integrase (HIV-1 IN) due to HIV-1 mutations. This study developed an efficient and chemo-selective method for synthesizing diverse C3 -> C6 diaryl 7-azaindoles that inhibit the strand transfer (ST) activity of HIV-1 IN enzyme. The synthesized compounds exhibited significant %ST inhibition, with para-substitution on the C3 aryl ring and C6 aryl being essential for enhanced %ST inhibition.
Article
Chemistry, Multidisciplinary
Taku Nakayama, Hidemasa Hikawa, Shoko Kikkawa, Isao Azumaya
Summary: A synthetic method for dehydrative N-benzylation promoted by water molecules in heptane using a pi-benzylpalladium system has been developed. The presence of water significantly accelerates carbon-nitrogen bond formation, which is accomplished in an atom-economical process to afford the corresponding N-monobenzylated products. Kinetic isotope effect measurements revealed that benzylic carbon-hydrogen bond cleavage was the rate-determining step.
Article
Chemistry, Organic
Qiang Huang, Lvjia Wu, Jihai Shi, Jiangdong Li, Wei Lu, Fushan Tang, Lei Zhu, Wenwu Zhong, Changkuo Zhao
Summary: An I-2/DTBP-promoted (3+2) cycloaddition reaction of 2-aminopyridines and chromones is reported, providing a simple and efficient approach to access imidazopyridines scaffold in moderate to good yields. This strategy has advantages such as readily available starting materials, excellent functional-group tolerance, potential drug activity of the products, and the ability to be produced on a gram scale. The obtained products also offer a key active fragment for the synthesis of cabozantinib analogues, with potential as an anticancer agent.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Multidisciplinary
Arnaud de Zordo-Banliat, Kevin Grollier, Nicolas Vanthuyne, Sebastien Floquet, Thierry Billard, Guillaume Dagousset, Bruce Pegot, Emmanuel Magnier
Summary: This study presents a method for the selective synthesis of perfluoroalkyl selenoxides and selenones using Oxone (R) as an oxidant or a Polyoxometalate-based Ionic Liquid (POM-IL) as a catalyst. The reaction provides satisfactory to excellent yields for various perfluoroalkyl chains and substituents. Perfluoroalkyl selenoxides are obtained through a two-step one-pot reaction from selenocyanates, and the previously unknown perfluoroalkyl selenoximines family is prepared with good yields. Two strategies for the synthesis of fluoroalkylated Se-IV and Se-VI compounds are explored, and the lipophilicity parameters of these compounds are evaluated. Additionally, the absolute configurations of asymmetric aryl perfluoroalkyl selenoximines are determined through resolution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Organic
Qi Chen, Sihong Chen, Hanqing Wu, Xiaoqing Zeng, Weiqing Chen, Guoxing Sun, Zhaoyang Wang
Summary: Aminopyridine is a significant synthetic synthon with a dual nucleophilic structure, which has been widely studied for its cyclization reactions in recent years. The synthesis of various azaheterocycles based on 2-aminopyridines has shown potential applications in organic synthesis methodology, drug development, and fluorescent probe synthesis. Future developments are focused on green cyclization and expanding applications of 2-aminopyridines.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Aakanksha Gurawa, Manoj Kumar, Sudhir Kashyap
Summary: The developed protocol allows for selective deprotection of acetyl groups in a wide range of substrates, including carbohydrates, amino acids, natural products, heterocycles, and general scaffolds. The environmentally friendly reagent system used in this method enables clean transformations under ambient conditions.
Article
Chemistry, Organic
Sheba Ann Babu, P. V. Varsha, Susanna Poulose, Sunil Varughese, Jubi John
Summary: We have developed a direct method for the synthesis of polycyclic imidazo[1,2-a]pyridines via a copper-catalyzed annulation reaction. By using 3-nitroindoles and 2-aminopyridine, tetracenes, namely indole-fused imidazo[1,2-a]pyridines, can be synthesized. Pentacenes, namely indolo-imidazo[1,2-a]quinolines, can be generated from 2-aminoquinoline. Furthermore, benzothieno-imidazo[1,2-a]pyridines can be synthesized starting from 3-nitrobenzothiophene. The photophysical properties of these synthesized heteroacenes were also evaluated.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemical Research Methods
Wei Wei, Changyong Wang, Jianfeng Zhang, Lele Wang, Lei Wei, Hairong Huang
Summary: This study aims to explore the regulatory mechanism of lncRNA LINC01234 in non-small cell lung cancer (NSCLC). The results showed that LINC01234 was abundantly expressed in NSCLC cells. LINC01234 competitively bound to miR-433-3p and promoted GRB2 transcription to augment NSCLC cell malignant proliferation.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Materials Science, Multidisciplinary
Shuai Chen, Kunqi Hou, Ting Li, Xihu Wu, Zhe Wang, Lei Wei, Wei Lin Leong
Summary: This article reports a highly stable and comfortable fibrous electrolyte with potential applications in on-skin electronics.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Food Science & Technology
Yingying Ke, Jun Chen, Taotao Dai, Min Xiao, Mingshun Chen, Ruihong Liang, Wei Liu, Chengmei Liu, Liqing Du, Lizhen Deng
Summary: This study investigated the effects of pressure changes on the color, nutrition, and flavor of whole mango juice treated by an industry-scale microfluidizer system. The results showed that the system maintained the physical properties of the juice and improved its antioxidant activity. Therefore, the system has the potential to produce high-quality whole mango juice on an industrial level.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Qiang Li, Lei Huang, Wei Liu, Lifang Feng, Xinzhu Chen
Summary: This work addresses the problem of acquiring visible satellites using an antenna array in the presence of impulsive noise. The joint angle and number estimation of visible satellites is formulated as a joint l(1,1)-norms minimization problem by exploiting the spatial sparsity of visible satellites. To obtain a closed-form solution, a generalized conjugate function for complex-valued matrix variable is introduced and the joint l(1,1)-norms minimization is transformed into a Lagrangian dual function maximization. The effectiveness of the proposed approach is demonstrated through numerical results.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Liheng Gao, Xingxing Liu, Wenshuo Zhao, Chaojin Li, Fujun Wang, Jing Gao, Xinqin Liao, Lei Wei, Hao Wu, Yuanjin Zheng, Lu Wang
Summary: Dynamic regulation of wound physiological signals is essential for wound healing. Conventional biomaterials delivering growth factors often lead to passive repair of soft tissues due to mismatch with wound healing stages, and wound exudate bioactivity is limited by oxidation and bacterial contamination. In this study, a nanofiber/hydrogel interpenetrated network (NFHIN) was developed to balance the wound microenvironment and collect and activate wound exudate for effective wound healing. The NFHIN showed promising potential in wound care for critical skin diseases.
Editorial Material
Engineering, Electrical & Electronic
Wei Liu, Arjuna Madanayake, Lei Yu, Qing Shen, Jingjing Cai
INTERNATIONAL JOURNAL OF ANTENNAS AND PROPAGATION
(2023)
Article
Chemistry, Medicinal
Wei Liu, Chenggao Wu, Qian Wang, Linju Kuang, Aiping Le
Summary: In this study, the researchers investigated the mechanisms by which Tanshinone IIA (TIIA) affects RA fibroblast-like synoviocytes (RA-FLSs). They used a mouse model of RA called collagen-induced arthritis (CIA) and manipulated matrix metalloproteinase9 (MMP9), receptor for advanced glycation end product (RAGE), and toll-like receptor 9 (TLR9) in both mice and RA-FLSs to study the effects of TIIA. The results showed that TIIA inhibited the proliferation of RA-FLSs, affected autophagy, and improved the symptoms of RA in mice by inhibiting the expression of MMP9 and the activation of TLR9 via the RAGE pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Engineering, Chemical
Zhiqiang Guo, Huimin Shangguan, Qianwei Liu, Yinhe Li, Xingjiang Liu, Ailing Sun, Yuhan Li, Liuhe Wei
Summary: This study synthesized a hydroxyl silane coupling agent (HO-silane) through a click reaction and used it for moisture-cured silane-modified polyurethane (SPU) resin. The influence of the molar ratio of -NCO and -OH (r value) on the characteristics of SPU resins was investigated. A SPU resin with desirable properties and a silane-modified polyurethane (MS) sealant with high tensile strength and elongation at break could be produced using the synthesized HO-silane.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Bicheng Wang, Yu Yao, Wenting Hong, Zhaoan Hong, Xu He, Taiku Wang, Chuanyong Jian, Qiankun Ju, Qian Cai, Zhihua Sun, Wei Liu
Summary: A molecular sieve-assisted strategy is used to synthesize ultrathin 2D iron sulfide with different phases. Hexagonal FeS, tetragonal FeS, and non-stoichiometric Fe7S8 can be precisely synthesized by tuning the growth temperatures. The synthesized 2D iron sulfides exhibit high conductivity, superconductivity, and ferrimagnetism, providing a potential route for synthesizing other 2D compounds with different phases.
Article
Food Science & Technology
Dantong Li, Taotao Dai, Mingshun Chen, Ruihong Liang, Wei Liu, Chengmei Liu, Jian Sun, Jun Chen, Lizhen Deng
Summary: The study investigated the changes in quality and volatile properties of mangoes at different ripening stages during infrared drying. Results showed variations in total soluble solids/titratable acid, texture, nutrient composition, and volatile compounds during drying. Fruits at RS-3 stage exhibited the highest increase in total phenolic content, the most dramatic decrease in vitamin C content, and the lowest decrease in beta-carotenoid contents. The evaluation score at RS-3 was the highest among all stages, indicating its superior quality.
Article
Cardiac & Cardiovascular Systems
Yan Liu, Da Huang, Zhile Li, LiuFang Zhou, Tuan Cen, Baomin Wei, Liuqing Wei, Hongying Wu, Liye Su, Suren R. Sooranna, Xinshou Pan, ZhaoHe Huang
Summary: This study investigated the pathogenesis of disease progression in patients with heart failure after acute myocardial infarction using plasma proteomics. A comparison of the plasma proteomes of acute myocardial infarction patients with and without heart failure revealed a group of proteins related to the NF-kappa B signaling pathway, which may be useful for the diagnosis and pathophysiology research of MI-HF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Psychology, Social
Xinyi Zhang, Alex English, Thomas Talhelm, Benjamin H. Nam, Liuqing Wei
Summary: The study found regional differences in anxiety levels during the pandemic in China. People in rice-farming areas reported higher anxiety levels compared to those in wheat-farming areas. This relationship was mediated by collectivism and social norm tightness.
SOCIAL AND PERSONALITY PSYCHOLOGY COMPASS
(2023)
Article
Chemistry, Analytical
Chenying He, Yuanao Zhang, Ting Wen, Shenghai Pei, Zhixun Wang, Juan Xia, Guangcheng Xi, Wenjie Li, Jiahong Wang, Guoqiang Gu, Guohua Zhong, Lei Wei, Chunlei Yang, Ming Chen
Summary: A novel oxygen vacancy heteropolyacid (HFMO) is developed as a high-performance volume-enhanced Raman scattering (VERS)-active platform, which forms a special coordination bond with the probe molecule at the molecular level. This platform has excellent VERS enhancing effect and high selectivity for molecules containing the imino group. Rating: 9 out of 10.
ANALYTICAL CHEMISTRY
(2023)
Article
Computer Science, Information Systems
He Xu, Wei Liu, Ming Jin, Ye Tian
Summary: This article proposes an AV positioning method based on DOA estimation under unknown mutual coupling, which achieves enhanced and closed-form DOA estimation by exploiting ULAs, Toeplitz rectification, and phase transformation. A more reliable subset/set of DOAs is constructed based on signal-to-noise ratio, and robust AV positioning is achieved with this subset/set. Additionally, an AV contour extraction scheme is developed using two antennas installed on the AV, showing improved resolution and accuracy, reduced computational complexity, robustness to mutual coupling and unreasonable DOA estimates, and effective AV contour information extraction.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Review
Materials Science, Multidisciplinary
Dan Zhu, Zhenyu Zhang, Min Chen, Pan Li, Yuanzhuo Xiang, Jingyu Ouyang, Zhiheng Huang, Xiaojuan Liu, Fuhong Wang, Maiping Yang, Hongtao Zeng, Ping Hong, Lei Wei, Chong Hou, Guangming Tao
Summary: This paper proposes an advanced performance analysis system powered by intelligent fabric for rhythmic gymnasts. The system uses intelligent fabric to detect physiological and anthropometric data, and employs artificial intelligence techniques for behavior recognition and decision-making, providing personalized suggestions. Additionally, four typical applications are presented to improve training performance.
ADVANCED FIBER MATERIALS
(2023)
