4.8 Article

Synthesis of 2-Indolylphosphines by Palladium-Catalyzed Annulation of 1-Alkynylphosphine Sulfides with 2-Iodoanilines

Journal

ORGANIC LETTERS
Volume 12, Issue 7, Pages 1476-1479

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1001544

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Funding

  1. JSPS

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Palladium-catalyzed annulation of 1-alkynylphosphine sulfides with 2-iodoanilines followed by desulfidation affords 3-substituted 2-indolylphosphines. This annulation/desulfidation sequential protocol offers a conceptually new approach to bulky heteroarylphosphines.

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