Journal
ORGANIC LETTERS
Volume 12, Issue 20, Pages 4502-4505Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1018008
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- National Institute of Health, General Medical Sciences division [GM 72572]
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The conversion of a cycloheptannelated indole platform into the heptacyclic core structure of dragmacidin E proceeded over nine steps. Key sequences include a cyclocondensation to form an intermediate dihydropyrazinone ring and the conversion of a cyclic urea into the cyclic guanidine of the target
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