4.8 Article

Efficient Diacetoxylation of Alkenes via Pd(II)/Pd(IV) Process with Peracetic Acid and Acetic Anhydride

Journal

ORGANIC LETTERS
Volume 12, Issue 11, Pages 2450-2452

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1001686

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Funding

  1. National Institutes of Health [RO1 GM 71495, S10 RR025432]

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A palladium-catalyzed diacetoxylation of alkenes in the presence of peracetic acid and acetic anhydride was developed to produce diacetates efficiently and diastereoselectively. Due to its mild conditions, this method was suitable for a broad range of substrates encompassing conjugated and nonconjugated olefins.

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