Journal
ORGANIC LETTERS
Volume 12, Issue 17, Pages 3788-3791Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol101451s
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- Ministere de l'Education Nationale et de la Recherche
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The first enantio- and diastereoselective approach to alpha-alkoxy-substituted syn-beta-hydroxyesters through highly efficient catalytic asymmetric transfer hydrogenation via dynamic kinetic resolution reactions from the corresponding racemic beta-ketoesters is described. In this atom-economical process, two contiguous stereogenic centers are generated simultaneously with an excellent diastereoselectivity (up to 99/1) and enantioselectivity (up to 99%), allowing a rapid access to a wide variety of aromatic and heteroaromatic monodifferentiated syn-1,2-diols.
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