Journal
ORGANIC LETTERS
Volume 12, Issue 11, Pages 2578-2581Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol100419y
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- COST action [BM0806]
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Iron-containing ligands targeting the human histamine H-3 receptor (hH(3)R) were prepared. The compounds contain ferrocene sandwich complexes coupled via different linkers to a basic hH(3)R antagonist/inverse agonist pharmacophore. In a click chemistry approach, a triazole was successfully inserted as a new linking element. Two ferrocenylmethylamines and a ferrocenyltriazole were the most affine hH(3)R ligands within this series, showing receptor binding in the nano- and subnanomolar concentration range.
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