Article
Chemistry, Physical
Jian-Shu Wang, Jiangjie Zhang, Siqi Wang, Jun Ying, Chuan-Ying Li, Xiao-Feng Wu
Summary: A novel palladium-catalyzed domino carbonylative cyclization has been developed for the rapid construction of functionalized heterocycles. The reaction proceeds smoothly with the consecutive formation of C-C and C-X bonds using benzene-1,3,5-triyl triformate as the CO source, yielding a variety of biologically relevant derivatives.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Yun Ye, Jie Zhu, Haijiao Xie, Yinhua Huang
Summary: A ligand-controlled rhodium-catalyzed reaction has been reported, which allows the synthesis of different structures of alkene products in a switchable manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Marina Yu. Dvorko, Dmitrii A. Shabalin, Igor A. Ushakov, Elena Yu. Schmidt, Boris A. Trofimov
Summary: The cascade dimerization of alkynones with sterically hindered secondary alkyl groups at the carbonyl function unexpectedly produced highly functionalized furans. This reaction efficiently takes place at room temperature in the presence of a potassium tert-butoxide/dimethylsulfoxide superbase catalytic system. Alkynones with an additional C-H active site at the carbon-carbon triple bond followed a different dimerization pathway to form 3-alkenylpyran-4-ones. The discovery of these reactions expands the traditional understanding of alkynone reactivity in strong basic conditions.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Rohit Kumar Maurya, Swadhapriya Bhukta, Keshav Kishor, Rana Chatterjee, Amarender Goud Burra, Mahender Khatravath, Rambabu Dandela
Summary: Boron-containing organometallic compounds have always intrigued organic chemists due to their wide application in carbon-carbon bond formation reactions. This review focuses on the arylative cyclization reactions using boronic acids as substrates under different transition metals, for the synthesis of densely functionalized heterocycles and bioactive scaffolds. The study highlights the growing interest in the field and provides an overview of recent developments.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Hongbo Qi, Kaiming Han, Shufeng Chen
Summary: This study presents a convenient palladium-catalyzed domino cyclization reaction for the synthesis of bis(benzofuranyl)methane scaffolds bearing all-carbon quaternary center, in which multiple bonds and rings are formed in a single synthetic sequence through a cascade reaction. The approach demonstrates broad substrate scope and good functional-group tolerance, and has been successfully applied to the synthesis of benzofuranyl methyl chromane derivatives.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Deyuan Meng, Jing He, Woojin Yoon, Hoseop Yun, Jung Tae Han, Jaesook Yun
Summary: In this study, the catalytic 1,6-addition of chiral alkyl copper nucleophiles generated from borylalkenes and a copper-hydride catalyst was successfully conducted under mild conditions. The controlled chemo- and stereoselectivity played a crucial role in the reductive coupling process, resulting in efficient synthesis of asymmetric 1,6-adducts of p-quinone methides through multicomponent and catalytic tandem reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Yimin Hu, Wangyu Shi, Zhengyang Yan, Jianning Liao, Min Liu, Jiaqing Xu, Wei Wang, Yongjun Wu, Cheng Zhang, Hongchao Guo
Summary: An efficient method using K2CO3 catalysis has been developed for the 1,4-addition/intramolecular cyclization/aromatization reaction of aurone-derived 1-azadienes with trisubstituted allenoates, resulting in a series of benzofuro[3,2-b]pyridines in moderate to excellent yields. The reaction proceeds efficiently under an air atmosphere without the need for transition metal catalysts, providing a concise approach to benzofuro[3,2-b]pyridines.
Article
Chemistry, Organic
Huawei Lin, Xianru Yang, Wenyue Ning, Xiaofang Huang, Xiaoqun Cao, Yanqing Ge, Biming Mao, Chang Wang, Hongchao Guo, Chunhao Yuan
Summary: Nitrogen-containing heterocycles play crucial roles in biologically active natural products and pharmaceuticals, and the palladium-catalyzed decarboxylative cycloaddition reactions are powerful synthetic tools. Vinyl benzoxazinones have emerged as versatile building blocks for nitrogenous skeletons.
Article
Chemistry, Multidisciplinary
Debasis Pal, Timothy B. Wright, Ryan O'Connor, P. Andrew Evans
Summary: The developed method utilizes rhodium catalysis for regio- and diastereoselective allylic substitution reactions, demonstrating high selectivity without the need for exogenous ligands. It is tolerant of various benzylzinc nucleophiles and functionalized aliphatic allylic electrophiles. Additionally, it exploits the configurational fluxionality of the rhodium-allyl intermediate for the construction of vicinal acyclic ternary/ternary stereogenic centers and cyclic ternary/quaternary derivatives.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Maximilian Scheruebl, Constantin G. Daniliuc, Armido Studer
Summary: The article introduces the application of arynes as radical acceptors, showing how the stable radical TEMPO can react with different ortho-substituted benzynes to generate aryl radicals for subsequent cyclizations, eventually being trapped by TEMPO. This method provides a novel approach for the convenient synthesis of various dihydrobenzofurans, oxindoles, and sultones.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Yulei Zhao, Shai Li, Yuhang Fan, Huimin Wang, Xin Kang, Zhongyin Ji, Laijin Tian
Summary: A method for the rapid synthesis of polycyclic 3,3'-biindole derivatives has been developed using AgOTf-catalyzed nucleophilic addition and cycloisomerization processes. The reaction is efficient and takes only a few minutes, resulting in moderate to good yields of functionalized polycyclic 3,3'-biindoles.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Tobias Wagener, Marco Pierau, Arne Heusler, Frank Glorius
Summary: In this study, a one-pot protocol for the synthesis of octahydroindoles, decahydroquinolines, and octahydroindolizines through a cascade reaction is presented.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Andrew Whyte, Jonathan Bajohr, Ramon Arora, Alexa Torelli, Mark Lautens
Summary: An enantioselective consecutive cyclization/coupling process catalyzed by palladium was reported in this study. The stereoinduction was achieved through an enantioselective carbopalladation, leading to the generation of an intermediate that promotes a nucleopalladation step. This dual cyclization sequence was compatible with various nucleophiles and aryl iodides, producing numerous bisheterocycles in good yields and high regio- and enantioselectivities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Raffaella Mancuso, Patrizio Russo, Melania Lettieri, Domenico Santandrea, Corrado Cuocci, Bartolo Gabriele
Summary: Polycyclic heterocyclic derivatives can be synthesized in one step by a carbonylative double cyclization approach, with yields ranging from 45% to 86%, showing promising potential for various applications.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Chunxiang Pan, Gaowei Wang, Hengyuan Zhao, Jianxiao Ni, Ruifeng Fan, Yongyun Zhou, Yuanbin Zhu, Shiyuan Wu, Baomin Fan
Summary: An efficient stereoselective cobalt-catalyzed hydrovinylative cyclization of 1,6-enynes with chalcones to obtain functionalized pyrrolidines has been developed. The products were furnished in good yields with up to 93% ee. A plausible mechanism through which the transformation was initiated by cyclization of 1,6-enynes is proposed.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Applied
Tae Yun Ko, So Won Youn
ADVANCED SYNTHESIS & CATALYSIS
(2016)
Article
Chemistry, Organic
Su San Jang, So Won Youn
ORGANIC & BIOMOLECULAR CHEMISTRY
(2016)
Article
Chemistry, Organic
So Won Youn, Eun Mi Lee
Review
Chemistry, Organic
So Won Youn, Tae Yun Ko
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Organic
So Won Youn, Tae Yun Ko, Young Ho Kim, Yun Ah Kim
Article
Chemistry, Organic
Huen Ji Yoo, So Won Youn
Review
Chemistry, Organic
So Won Youn
SYNTHESIS-STUTTGART
(2020)
Article
Chemistry, Organic
Su San Jang, Young Ho Kim, So Won Youn
Article
Chemistry, Organic
Young Ho Kim, Dong Bin Kim, Su San Jang, So Won Youn
Summary: A Pd-catalyzed intramolecular allylic C-H amination method has been developed, allowing for the synthesis of diverse 1,3-X,N-heterocycles through selective allylic C-H cleavage and pi-allylpalladium formation. The use of substrates containing a labile allylic moiety and new catalytic systems overcomes significant challenges for achieving highly chemo- and regioselective allylic C-H amination.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Young Ho Kim, Dong Bin Kim, So Won Youn
Summary: A simple and efficient one-pot process for the synthesis of diverse 2-alkyl-substituted 1,3-X,N-heterocycles through tandem olefin isomerization/intramolecular hydroamination has been developed. The process utilizes AgOTf catalyst and offers advantages such as high chemical yields, good functional group tolerance, and broad substrate scope.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Organic
So Won Youn, Cheon-Gyu Cho
Summary: This review provides a brief overview of recent progress in transition-metal-catalyzed direct ortho-selective C-H functionalization of free phenols, which is of great importance in synthetic research.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Young Ho Kim, Huen Ji Yoo, So Won Youn
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Applied
So Won Youn, Huen Ji Yoo, Eun Mi Lee, Seo Young Lee
ADVANCED SYNTHESIS & CATALYSIS
(2018)
Article
Chemistry, Applied
So Won Youn, Huen Ji Yoo
ADVANCED SYNTHESIS & CATALYSIS
(2017)
Article
Chemistry, Multidisciplinary
So Won Youn, Tae Yun Ko, Young Ho Jang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)