4.8 Article

Desymmetrizations Forming Tetrasubstituted Olefins Using Enantioselective Olefin Metathesis

Journal

ORGANIC LETTERS
Volume 12, Issue 9, Pages 2032-2035

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100511d

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Funding

  1. NSERC (Canada)
  2. FQRNT (Quebec)
  3. CFI (Canada)
  4. Bochringer Ingelheim (Canada) Ltd.
  5. Merck Frosst Centre for Therapeutic Research
  6. Universite de Montreal

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Highly reactive chiral Ru-based catalysts possessing C-1-symmetric N-heterocyclic carbene ligands adorned with one N-alkyl group and one N-aryl group were evaluated in asymmetric desymmetrizations to form cyclic products possessing a tetrasubstituted olefin.

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