4.8 Article

A General and Efficient Copper Catalyst for the Double Carbonylation Reaction

Journal

ORGANIC LETTERS
Volume 11, Issue 6, Pages 1321-1324

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol9001027

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Funding

  1. Chinese Academy of Sciences
  2. National Natural Science Foundation of China [20625308, 20873166]

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The use of (NHC)CuI complex in combination with a N-heterocyclic carbene precursor as catalyst for the double carbonylation of aryl Iodides and secondary amines solves the problem of using the precious metal Pd and phosphine ligands. The new protocol requires a nonprecious metal catalyst and has greater generality than those previously reported.

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