Journal
ORGANIC LETTERS
Volume 11, Issue 5, Pages 1083-1086Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8028687
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Funding
- Xunta de Galicia [PGIDIT07PXIB314174PR]
- Spanish Ministerio de Ciencia y Educacion [CTQ2008-06647-C02]
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A now Pd-catalyzed tandem Intramolecular oxypalladation/Heck-type coupling between 2-alkynylphenols and alkenes Is reported, leading to 3-(1-alkenyl)benzofurans. Participating alkenes include those substituted with an electron-withdrawing group (ester, ketone, amide, nitrile, sulfone), as well as styrene. Remarkably, beta-substituted-alpha,beta-unsaturated carbonyl-type derivatives also participate effectively. The ready availability of substituted alkynylphenols, together with flexibility in the alkene choice, makes this simple strategy a versatile one for the synthesis of structurally diverse benzofuran derivatives.
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