Journal
ORGANIC LETTERS
Volume 11, Issue 23, Pages 5374-5377Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9020404
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- NSF
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The combination of catalytic amounts of [(R)-DTBM-SEGPHOS]CuH in the presence of stoichlometric DEMS (diethoxymethylsilane) In toluene at room temperature leads to asymmetric reductions of 4-substituted coumarins. Several targets or their known precursors can be prepared in high yields and ee's, including the muscarine receptor antagonist (R)-tolterodine.
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