Journal
ORGANIC LETTERS
Volume 11, Issue 7, Pages 1651-1654Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol900306v
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Funding
- NIH/NIGMS [GM73072]
- Abbott Laboratories
- Amgen
- AstraZeneca
- GlaxoSmithKline
- Sloan Foundation
- Boehringer-Ingelheim
- GAANN Fellowship
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Indoles and alcohols can be coupled in a dehydrogenative process catalyzed by tetra propylammonium perruthenate. This efficient approach to indolylamides proceeds in a single flask under mild conditions. By employing substituted indoles and alkyl, branched, or benzylic alcohols, a variety of indolylamides can be formed. Aryl indolylamides can be functionalized through an additional dehydrogenative coupling to furnish elaborated polycyclic heterocycles similar to biologically active structures previously reported.
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