Journal
ORGANIC LETTERS
Volume 11, Issue 2, Pages 489-492Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol802710u
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- National Institute of General Medical Sciences [GM60567]
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A total synthesis of brevetoxin A is reported. Two tetracyclic coupling partners, prepared from previously reported advanced fragments, were effectively united via a Horner-Wittig olefination. The resulting octacycle was progressed to substrates that were explored for reductive etherification, the success of which led to a penultimate tetraol intermediate. The tetraol was converted to the natural product through an expeditious selective oxidative process followed by methylenation.
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