Journal
ORGANIC LETTERS
Volume 11, Issue 17, Pages 3806-3809Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901243e
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Funding
- National Institutes of Health ES012619 and GM66712 [ES012619, GM66712]
- NYSTAR
- Korea Research Foundation funded by the Korean government (MOEHRD) [KRF-2006-352-D00047]
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Polyketide analogues are produced via in vitro reconstruction of a precursor-directed polyketide biosynthetic pathway. Malonyl-CoA synthetase (MCS) was used in conjunction with chalcone synthase (CHS), thereby allowing efficient use of synthetic starter molecules and malonate as extender. Coenzyme-A was recycled up to 50 times. The use of a simple immobilization procedure resulted in up to a 30-fold higher yield of pyrone CHS products than that obtained with the free enzyme solutions.
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