Article
Multidisciplinary Sciences
Tianchen Wu, Manoj Kumar, Jing Zhang, Shengyu Zhao, Mikhail Drobizhev, Mason McCollum, Charles T. Anderson, Ying Wang, Antje Pokorny, Xiaodong Tian, Yiyu Zhang, Thanos Tzounopoulos, Hui-wang Ai
Summary: A genetically encoded far-red fluorescent indicator, FRISZ, was developed to monitor synaptic Zn2+ dynamics in the nervous system. The indicator was anchored to the mammalian extracellular membrane and successfully used to image synaptic Zn2+ in brain slices and awake mice. This study establishes a new technology for studying the roles of synaptic Zn2+ in the nervous system.
Article
Chemistry, Physical
Serkan Erdemir, Sait Malkondu
Summary: A novel probe RHI was designed and synthesized for sensitive and specific sensing of metal ions, showing potential for biological and environmental applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Analytical
Jianfei Liu, Jie Li, Jun Tang, Xiaopeng Yang, Di Zhang, Yong Ye, Yufen Zhao
Summary: Mercury and sulfur dioxide are common pollutants in the environment, affecting organisms and causing diseases. A bifunctional fluorescent probe LJ was designed to detect Hg2+ and SO2 simultaneously with high sensitivity. The study suggests that SO2 can be used as an antidote to mitigate the toxicity of Hg2+ in living cells.
Article
Chemistry, Physical
Liang Zhang, Jing Wang, Huiting Wang, Wentao Zhang, Wenxin Zhu, Ting Du, Yongsheng Ni, Xianghong Xie, Jing Sun, Jianlong Wang
Summary: This study successfully constructed a smart adsorbent NSU66 with mixed-ligand and hierarchical-pore structure using the SALE approach, which can simultaneously sense and remove Hg2+ in water with high efficiency. NSU66 shows significant improvements in sensing and trapping capabilities compared to NU66, indicating promising application prospects.
Article
Chemistry, Inorganic & Nuclear
R. Behura, P. Mohanty, G. Sahu, P. P. Dash, S. Behera, R. Dinda, P. R. Hota, H. Sahoo, R. Bhaskaran, A. K. Barick, P. Mohapatra, Bigyan R. Jali
Summary: In pharmacological, environmental, biological, and material research, the design and synthesis of new fluorescence chemosensors based on Schiff base derivatives are crucial. A novel Schiff base compound (L) based on 2,4-dinitrophenyl hydrazine was designed and characterized for the selective detection of Zn2+, Cd2+ and Hg2+ ions. Probe L showed weak fluorescence emission in DMSO-H2O (10:90, v/v) due to isomerization of the C--N bond and photoinduced electron transfer processes, but it exhibited enhanced fluorescence emission upon addition of Zn2+, Cd2+, and Hg2+ ions, making it a unique chemosensor for these ions.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Rafal Kosman, Adam Olejniczak, Miroslawa Pawlyta, Oleksii Bezkrovnyi, Bartlomiej Cichy
Summary: This work investigates the spectral implications of doping AgInS2 quantum dots with Zn2+ and its higher homologues Cd2+ and Hg2+. The study utilizes comprehensive spectroscopic measurements and theoretical predictions to analyze the effects of alloying AgInS2 quantum dots with IIB group atoms. It is observed that each admixture induces a distinct spectral response, with Cd2+ and Hg2+ ions showing a complete reversal of character. The differences in spectra are associated with changes in defect structures and relaxation pathways. The study finds that Zn2+ ions have a weak impact on the emission properties, while Cd2+ and Hg2+ ions have the highest impact. Doping with Cd2+ deactivates relaxation pathways, resulting in shortened photoluminescence lifetime and partial band symmetrization. Conversely, doping with Hg2+ ions leads to the formation of metallic Hg-Ag complexes on the surface, displaying anomalous behavior in Hg-doped AgInS2 quantum dots.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Jasim M. S. Alshawi, Mohammed Q. Mohammed, Hasan F. Alesary, Hani K. Ismail, Stephen Barton
Summary: A novel electrochemical sensor based on a platinum electrode modified by poly(3,4-ethylenedioxythiophene) and N alpha,N alpha-bis-(carboxymethyl)-L-lysine hydrate (NTA lysine) was developed for determining trace levels of Hg2+, Pb2+, and Zn2+ ions in water using square wave voltammetry. The modified electrode was characterized and the electrochemical properties were investigated. The sensor showed linear responses and low detection limits for Hg2+, Pb2+, and Zn2+ ions.
Article
Environmental Sciences
Deepti Chauhan, Anil Kumar, Sudhir G. Warkar
Summary: The article investigates the real-time application of m-BPDM embedded PAM/CMG hydrogel sensor, which shows high selectivity for Zn2+, Cd2+, and Hg2+ ions. The hydrogel effectively detects and distinguishes these metal ions in industrial effluents without the need for pretreatment of the effluent.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Baoquan Xiao, Jie Chen, Changfa Hu, Lianshan Mou, Wenjing Yang, Wenhao He, Zhibin Lu, Shanglong Peng, Juanjuan Huang
Summary: In situ liquid-phase growth exfoliation is developed to obtain V5O12 nanosheets, which are then combined with Ti3C2 nanosheets to construct a 2D heterostructure HVO@Ti3C2. The dynamic interface coupling during discharging/charging provides a reversible electron transfer channel and promotes the insertion of more Zn2+, leading to an ultra-high capacity and high stability in AZIBs. This interface coupling mechanism provides an exciting strategy for the high energy density and high stability of AZIBs.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Applied
Mukul Bikash Maity, Suprava Bhunia, Arka Patra, Panchanan Sahoo, Snehasis Mishra, Chittaranjan Sinha
Summary: A diformylphenol Schiff base of triazole-amine was synthesized and characterized. The probe, PTR, showed strong and selective emission at 610 nm upon interaction with Zn2+ ion in a solution containing 15 other cations. The limit of detection for Zn2+ was found to be much lower than the recommended value. Additionally, PTR was able to identify intracellular Zn2+ ions in living cells using fluorescence microscopy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Qin Wang, Yupeng Shi, Wandi Chen, Mo Yang, Changqing Yi
Summary: The dual-functional nanoprobe designed in this study showed excellent performance in simultaneous detection of Zn2+ and pH with fast response in pure aqueous solution. It also demonstrated the capability of distinguishing cancerous cells from normal cells, which could be significant for cancer diagnosis and fluorescence-guided surgery.
Article
Environmental Sciences
D. Chauhan, A. Kumar, S. G. Warkar
Summary: The meta-benziporphodimethene (meta-BPDM) ligand immobilized in polyacrylamide/carboxymethyl guar gum (PAM/CMG) hydrogel is highly efficient for selectively removing Zn2+, Cd2+, and Hg2+ ions from water, with the best adsorption occurring at pH 6.5. Adsorption equilibrium was reached in 8 hours for Zn2+, 12 hours for Cd2+, and 6 hours for Hg2+. The hydrogel demonstrated superior adsorption capacity and selectivity, especially towards Hg2+ ions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Article
Crystallography
Abdel Majid A. Adam, Tariq A. Altalhi, Samy M. El-Megharbel, Hosam A. Saad, Moamen S. Refat
Summary: The study synthesized a modified fluorescent dendrimer that can capture hazardous heavy metal ions, providing basic data for a clean environment in the future. Through various analytical methods, it was found that the synthesized complexes have specific physicochemical properties that can differentiate the complexes of different metal ions.
Article
Spectroscopy
Lijuan Chen, Huie Jiang, Nihao Li, Qingjun Meng, Zhijian Li, Qingxin Han, Xinhua Liu
Summary: A Schiff-based fluorescent probe was developed for selective and sensitive detection of Zn2+ in aqueous solution, showing potential for on-site applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Balasaheb D. Vanjare, Prasad G. Mahajan, Hyang-Im Ryoo, Nilam C. Dige, Nam Gyu Choi, Yohan Han, Song Ja Kim, Chong-Hyeak Kim, Ki Hwan Lee
Summary: A novel fluorescent chemosensor PS based on rhodamine 6G has been synthesized and shown strong selectivity and sensitivity for Hg2+. The stoichiometry of the PS-Hg2+ complexes is 1:1, with a binding constant of 6 x 10(4) M-1. The fluorescence enhancement by Hg2+ binding in PS occurs significantly in the pH range of 6-8.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Multidisciplinary
Hai-Hao Han, Han-Min Wang, Paramesh Jangili, Mingle Li, Luling Wu, Yi Zang, Adam C. Sedgwick, Jia Li, Xiao-Peng He, Tony D. James, Jong Seung Kim
Summary: Cancer is a major global health problem, with millions of people diagnosed each year. Current chemotherapy options lack selectivity for cancer cells, are prone to resistance, and have toxicities. Researchers have focused on developing prodrug-based strategies to overcome these limitations. This review discusses recently developed prodrug strategies for cancer therapy and highlights the importance of targeting specific biomarkers in the tumor microenvironment and overexpressed in cancer cells. The advantages and limitations of each approach are also discussed.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Inorganic & Nuclear
Zhiqiang Mao, Ji Hyeon Kim, Jieun Lee, Hao Xiong, Fan Zhang, Jong Seung Kim
Summary: In recent years, BODIPY-based theranostics have been increasingly utilized in cancer therapy with remarkable success. By modifying the chemical structure, the optical imaging and phototherapy properties of BODIPY-based dyes can be well-balanced and tailored. Additionally, molecular/nanoparticle engineering allows versatile functionalities and improved tumor-targeting ability, enhancing the therapeutic efficacy and minimizing side effects. This review focuses on the applications of BODIPY-based theranostics in tumor therapy, including fluorescence-guided chemotherapy, photodynamic therapy, photothermal therapy, and multi-modal imaging-guided therapies.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Inorganic & Nuclear
Xiaorui Shi, Miae Won, Chu Tang, Qihang Ding, Amit Sharma, Fu Wang, Jong Seung Kim
Summary: The RNA splicing process is essential for gene expression, and monitoring and controlling it can help repair mutant genes and treat diseases. However, the lack of appropriate tools hampers the understanding of splicing regulation.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Oncology
Zhe Yang, Di Gao, Jing Zhao, Gaojie Yang, Ming Guo, Ying Wang, Xuechun Ren, Jong Seung Kim, Lin Jin, Zhongmin Tian, Xingcai Zhang
Summary: Immunotherapy has revolutionized cancer treatment, but promoting antitumour immunity in patients with resistant tumours remains a challenge. Thermal therapies offer a promising approach by reprogramming the tumour microenvironment and promoting immune cell recruitment. This review summarizes the role of thermal therapies in combination with immunotherapies, as well as the development of thermal immuno-nanomedicines for cancer treatment.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuling Xu, Chonglu Li, Jusung An, Xin Ma, Jingfang Yang, Lishi Luo, Yun Deng, Jong Seung Kim, Yao Sun
Summary: Researchers synthesized a novel Pt(II) metallacycle (Pt1110) that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue. Pt1110 showed significantly improved photothermal conversion and O-1(2) generation compared to the ligand itself 1, and it was capable of light-induced sterilization under safe laser irradiation. Pt1110 also had little to no toxicity to cells. When incorporated into liposomes, Pt1110 NPs effectively promoted wound healing in infection and keratitis models upon laser irradiation, observed by NIR-II fluorescence imaging. This novel metal-coordinated supramolecular material has the potential to be a universal platform for phototherapy in deep tissue.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Minsu Park, Kyoung Sunwoo, Yoon-Jae Kim, Miae Won, Yunjie Xu, Jaewon Kim, Zhongji Pu, Mingle Li, Ji Young Kim, Jae Hong Seo, Jong Seung Kim
Summary: A study introduces a new method to selectively eliminate cancer stem cells by cutting off proton leaks on the inner mitochondrial membrane. A molecule channel blocker called Bo-Mt-Ge, derived from Gardenia jasminoides fruit extract, is developed. This study also identifies the mitochondrial uncoupling protein UCP2 as being closely correlated with the stemness of cancer stem cells, providing a new perspective for drug discovery targeting these cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
News Item
Chemistry, Multidisciplinary
Yunjie Xu, Jong Seung Kim, Mingle Li
Review
Chemistry, Multidisciplinary
Siyue Ma, Ji Hyeon Kim, Wei Chen, Lu Li, Jieun Lee, Junlian Xue, Yuxia Liu, Guang Chen, Bo Tang, Wei Tao, Jong Seung Kim
Summary: Targeted fluorescent prodrugs that efficiently accumulate in tumor cells in different organs have shown great potential in improving drug targeting efficacy for tumor therapy. In this review, the development of innovative targeted fluorescent prodrugs for lung cancer, liver cancer, cervical cancer, breast cancer, glioma, and colorectal cancer is highlighted. The latest progress in chemical design and synthetic considerations, as well as the activation of therapeutic efficacy and fluorescence by tumor-specific stimuli, are reviewed. Furthermore, novel perspectives on engineered nanoparticle platforms and their use in monitoring the delivery of therapeutic agents in preclinical models are provided.
Review
Chemistry, Multidisciplinary
Zhiqiang Mao, Hyeonji Rha, Jungryun Kim, Xinru You, Fan Zhang, Wei Tao, Jong Seung Kim
Summary: Near-infrared fluorescence imaging is crucial for studying the biological world. However, the short emissions and small Stokes shifts of current xanthene dyes have limited their biological applications. A new technique involving THQ structural modification has been developed, which allows for longer emission wavelengths and larger Stokes shifts in THQ-modified xanthene dyes. This opens up possibilities for various applications of THQ-xanthene in fluorescence probe-based sensing and imaging, cancer theranostics, and super-resolution imaging.
Article
Chemistry, Multidisciplinary
In-Hwan Choi, Ja-Min Gu, Hyun-Chul Kim, Youngmee Kim, Seong Huh
Summary: A new three-dimensional Zn-MOF material with excellent gas sorption abilities has been synthesized.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Biomedical
Zehra Zunbul, Jusung An, Hira Aziz, Jinwoo Shin, Sungsu Lim, Le Yu, Yun Kyung Kim, Jong Seung Kim
Summary: Fluorescence imaging of amyloid beta (A beta) polypeptide using a small-molecule fluorophore is a practical system for Alzheimer's disease (AD) diagnosis. A molecular designing strategy for a new fluorogenic probe is suggested, with redshifted fluorescence emission wavelength and optimized binding affinities for A beta fibrils. Thioflavin T (ThT)-derived fluorescent dyes are developed by adjusting the hydrophobicity of electron donor moiety, resulting in significantly sensitive fluorogenic probes for bioimaging in AD.
ADVANCED NANOBIOMED RESEARCH
(2023)
Article
Chemistry, Organic
Seungjin Lee, In Guk Park, Jin Won Choi, Jin Young Son, Jin Woo Lee, Jae-Seoun Hur, Youngmee Kim, Sang-Jip Nam, Hahk-Soo Kang, Stephen T. Deyrup, Minsoo Noh, Sang Hee Shim
Summary: Three unprecedented caged xanthone [6,6,6,6,6] polyketides, Daldipyrenones A-C (1-3), were discovered from an endolichenic fungus, Daldinia pyrenaica 047188. The structures of 1-3 were determined using spectroscopic analysis and chemical derivatization. Daldipyrenones are likely formed by the combination of a chromane biosynthesis intermediate and a spiro-azaphilone through radical coupling or Michael addition, resulting in the formation of a bicyclo[2.2.2]octane ring. Genome sequencing revealed two biosynthetic gene clusters responsible for the formation of two biosynthetic intermediates, suggesting a proposed biosynthetic pathway. Daldipyrenone A (1) exhibited significant antimelanogenic activity and moderate adiponectin-secretion promoting activity with lower EC50 values than positive controls.
Review
Chemistry, Multidisciplinary
Nayeon Kang, Subin Son, Sunhong Min, Hyunsik Hong, Chowon Kim, Jusung An, Jong Seung Kim, Heemin Kang
Summary: Ferroptosis, an iron-dependent programmed cell death mechanism, can be regulated by intracellular iron supplementation and glutathione synthesis inhibition. Utilizing various endogenous and exogenous stimuli, such as tumor microenvironment conditions and external energy sources, can provide precise control and controllability for ferroptosis-based cancer therapy. The utilization of dual stimuli provides a new direction for efficient cancer therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Materials Science, Biomaterials
Le Tu, Qian Li, Sheng Qiu, Meiqin Li, Jinwoo Shin, Pan Wu, Nem Singh, Junrong Li, Qihang Ding, Cong Hu, Xiaoxing Xiong, Yao Sun, Jong Seung Kim
Summary: This review article provides an overview of the recent development of carbon dots (CDs) in biomedical research. It highlights the crucial applications of CDs in biosensing, bioimaging, cancer therapy, and antibacterial applications. The challenges and future potential of CD-based biomedicine are also emphasized, enriching biomedical researchers' knowledge about the potential of CDs and the need for overcoming technical obstacles.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Minhyeok Choi, Nem Singh, Subin Son, Ji Hyeon Kim, Minjung Kang, Su Hong Park, Dong Hoon Choi, Chang Seop Hong, Jong Seung Kim
Summary: The discharge of chemicals and textile waste into industrial effluents significantly pollutes water, making it unbearable for humans and other organisms. Conventional water treatment processes are efficient in degrading stable organic dye molecules. However, there is a continuous demand for sustainable technology to degrade toxic organic pollutants. In this study, a porphyrin-based porous organic polymer (PNP) modified with platinum clusters (Pt@PNP) was developed to enhance the photocatalytic degradation of toxic organic dyes in water. This modified catalyst effectively decomposed carcinogenic organic dyes by generating reactive oxygen species (ROS) under mild light irradiation, and it showed high efficiency and recyclability.
MATERIALS CHEMISTRY FRONTIERS
(2023)
