4.8 Article

Direct synthesis of 1,3-diketones by Rh-catalyzed reductive α-acylation of enones

Journal

ORGANIC LETTERS
Volume 10, Issue 12, Pages 2405-2408

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol800660y

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1,3-Diketones were synthesized from alpha,beta-unsaturated ketones by treatment with acid chlorides and Et2Zn in the presence of RhCl(PPh3)(3). This is a very simple and extremely chemoselective reaction to give the adduct at the alpha-position of alpha,beta-unsaturated ketones.

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