Journal
ORGANIC LETTERS
Volume 10, Issue 21, Pages 4871-4874Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol801968b
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Funding
- Japan Society for the Promotion Of Sciences [19590108]
- Takeda Pharmaceutical Co. Ltd.
- Grants-in-Aid for Scientific Research [19590108] Funding Source: KAKEN
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Dibenzo[b,d]azepin-6-ones (2a,b) were separated by chiral HPLC into the aR- and aS-atropisomers with high stereochemical stability, and methylation at C7 of 2a stereoselectively gave the (aR*,7R*) isomer (4a), which converted to the thermodynamically stable (aS*,7R*) atropisomer (5a) after heating.
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