Journal
ORGANIC LETTERS
Volume 10, Issue 12, Pages 2377-2379Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol800592s
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A novel regioselective synthesis of aryl-substituted pyrazolines and pyrazoles has been developed. Substituted phenylhydrazines react with 3-butynol in the presence of a catalytic amount of zinc triflate to give pyrazoline derivatives. The resulting products are easily oxidized in a one-pot procedure to the corresponding pyrazoles.
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