Article
Psychiatry
S. Dominguez-Alonso, A. Carracedo, C. Rodriguez-Fontenla
Summary: Autism Spectrum Disorders (ASD) is a group of neurodevelopmental disorders characterized by difficulties in social interaction and communication. The study uses a newly developed tool called eQTpLot to analyze the largest ASD GWAS data, along with GWAS summary statistics from other studies, to identify genes associated with ASD.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Chemistry, Multidisciplinary
Rory M. Crean, Michal Biler, Marc W. van der Kamp, Alvan C. Hengge, Shina C. L. Kamerlin
Summary: This study investigates the link between the dynamics of the WPD-loop and catalysis rates in human protein tyrosine phosphatase 1B (PTP1B) and YopH from Yersinia pestis. Computational simulations reveal key residues and structural features responsible for differences in loop dynamics, as well as pathways for allosteric communication in these enzymes. The findings shed light on how PTP enzymes in the family may adapt to environmental changes and regulate their catalytic activities.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Harvey F. Fulo, Nicole J. Rueb, Robert Jr Jr Gaston, Paratchata Batsomboon, Kh Tanvir Ahmed, Amy M. Barrios, Gregory B. Dudley
Summary: Starting from a 17-step synthesis reported in the 1970s, researchers have developed a new synthesis method that only requires a longest linear sequence of 5 steps to successfully synthesize the key pharmacophore of the fungal natural product illudalic acid. A series of analogs featuring the same pharmacophore were prepared through a similar route, showing potent and selective inhibition on protein tyrosine phosphatases. Evidence supporting a postulated covalent ligation mechanism is provided.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nuwan P. N. Acharige, Mary Kay H. Pflum
Summary: Kinases and phosphatases play important roles in cellular signaling, with aberrant activity potentially leading to diseases. Phosphatases are less studied due to limited substrate identification methods. The development of K-BIPS provides a new tool to explore phosphatase biology by identifying unexpected substrates.
Review
Biochemistry & Molecular Biology
Malathi Bheri, Swati Mahiwal, Sibaji K. Sanyal, Girdhar K. Pandey
Summary: Protein phosphorylation and dephosphorylation are important reversible post-translational modifications, with protein phosphatases playing a key role in signaling networks. The classification and mechanism of phosphatases in plant systems still require further investigation.
Article
Chemistry, Multidisciplinary
Matthias Nobis, Shigeyoshi Inoue, Bernhard Rieger
Summary: A method for functionalizing Si-H containing substrates with vinyl substituted silacyclopropenes has been developed, allowing for the generation of multi-functional silacyclopropene derivatives, ranging from small molecules to polymeric materials such as polysiloxanes. This method offers access to a new class of functionalized materials with potential applications.
CHEMICAL COMMUNICATIONS
(2022)
Article
Plant Sciences
Fei-Hua Yao, Xiao Liang, Xin-Hua Lu, Xia Cheng, Lian-Xiang Luo, Shu-Hua Qi
Summary: Seven new decahydrofluorene-class alkaloids, pyrrospirones K-Q (1-7), were isolated from the marine-derived fungal strain Penicillium sp. SCSIO 41512. Compound 13 exhibited significant inhibitory activity against protein tyrosine phosphatases. Moreover, compounds 1, 2, 5, 8-10, 12, and 13 showed antibacterial activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Biochemistry & Molecular Biology
Andrew M. Mattei, Jonathan D. Smailys, Emma Marie Wilber Hepworth, Shanta D. Hinton
Summary: Pseudophosphatases, atypical members of the protein tyrosine phosphatase family, play important roles in physiology and pathophysiology as key regulators in signaling cascades. By investigating their involvement in diseases and pathologies, pseudophosphatases have emerged as potential therapeutic drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Christie L. Burton, Mathieu Lemire, Bowei Xiao, Elizabeth C. Corfield, Lauren Erdman, Janita Bralten, Geert Poelmans, Dongmei Yu, S-M Shaheen, Tara Goodale, Vanessa M. Sinopoli, Noam Soreni, Gregory L. Hanna, Kate D. Fitzgerald, David Rosenberg, Gerald Nestadt, Andrew D. Paterson, Lisa J. Strug, Russell J. Schachar, Jennifer Crosbie, Paul D. Arnold
Summary: The study investigated genetic variants associated with obsessive-compulsive (OC) traits and found shared genetic risk between OC traits and obsessive-compulsive disorder (OCD). The research identified a significant genetic variant for OC traits and demonstrated the feasibility of using trait-based approaches for genetic discovery in community samples.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Evan T. Liechty, Andrew Hren, Levi Kramer, Gregory Donovan, Anika J. Friedman, Michael R. Shirts, Jerome M. Fox
Summary: Neutral mutational drift is an important but underutilized source of biological diversity in protein biophysics. This study focuses on protein tyrosine phosphatase 1B (PTP1B) and investigates how neutral drift impacts its catalytic activity and stability. The findings suggest that neutral or mildly activating mutations can counteract deleterious ones, indicating a moderate activity-stability tradeoff. The study also shows that neutral mutations in allosterically influential sites are purged under biological selection, enriching for mutations outside of the active site.
Article
Biochemistry & Molecular Biology
Valerie Vinette, Isabelle Aubry, Hayley Insull, Noriko Uetani, Serge Hardy, Michel L. Tremblay
Summary: Metabolic reprogramming in cancer cells is regulated by tyrosine kinases and tyrosine phosphatases. Among the protein tyrosine phosphatase (PTP) superfamily, TC-PTP (PTPN2) has been identified as a key regulator of mitochondrial metabolism in cancer cells, with its inhibition resulting in functional defects in oxidative metabolism.
Article
Chemistry, Multidisciplinary
Lucia Tapia, Naiara Solozabal, Jordi Sola, Yolanda Perez, W. Todd Miller, Ignacio Alfonso
Summary: The study introduces a new approach to selectively protect tyrosine residues in peptides from phosphorylation by the Src TK enzyme using pseudopeptidic cages. Fluorescence emission titrations indicate that the most efficient cage inhibitors strongly bind peptide substrates, with a good correlation between binding constant and inhibitory potency. Further experimental evidence supports the proposed mechanism of selectively protecting substrates through supramolecular interactions, showcasing the potential of supramolecular complexes for modulating TK signaling.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Cell Biology
Caroline E. Nunes-Xavier, Laura Zaldumbide, Lorena Mosteiro, Ricardo Lopez-Almaraz, Nagore Garcia de Andoin, Pablo Aguirre, Maite Emaldi, Leire Torices, Jose I. Lopez, Rafael Pulido
Summary: Neuroblastoma is a type of cancer associated with early development and differentiation of neuroendocrine cells, and PTPs play a key role in cell growth and differentiation, potentially serving as biomarkers and molecular targets for neuroblastoma therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Deqiang Liu, Yiming Zhang, Hui Fang, Jinxiang Yuan, Lizhen Ji
Summary: Pseudophosphatases are a class of enzymes that mutate at the catalytically active site and play important roles in life processes and diseases. This review discusses the structures, action types, and signaling mechanisms of pseudophosphatases in various families.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Matteo Accorsi, Markus Tiemann, Leon Wehrhan, Lauren M. Finn, Ruben Cruz, Max Rautenberg, Franziska Emmerling, Joachim Heberle, Bettina G. Keller, Joerg Rademann
Summary: This study reports the discovery and investigation of pentafluorophosphato amino acids as novel phosphotyrosine biomimetics. Experimental and computational methods were used to demonstrate that these novel biomimetics have significantly enhanced binding affinity to the protein tyrosine phosphatase PTP1B, suggesting their potential value in drug molecule development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ziqing Qian, Curran A. Rhodes, Lucas C. McCroskey, Jin Wen, George Appiah-Kubi, David J. Wang, Denis C. Guttridge, Dehua Pei
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Organic
Walaa Bedewy, Hui Liao, Nageh A. Abou-Taleb, Sherif F. Hammad, Tamer Nasr, Dehua Pei
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Chemistry, Organic
Hui Liao, Dehua Pei
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Medicine, Research & Experimental
Dehua Pei, Kuangyu Chen, Hui Liao
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2018)
Article
Chemistry, Multidisciplinary
Curran A. Rhodes, Patrick G. Dougherty, Jahan K. Cooper, Ziqing Qian, Steffen Lindert, Qi-En Wang, Dehua Pei
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Multidisciplinary
George Appiah Kubi, Ziqing Qian, Souad Amiar, Ashweta Sahni, Robert Stahelin, Dehua Pei
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Review
Biochemical Research Methods
Dehua Pei, Marina Buyanova
BIOCONJUGATE CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Brian J. Caldwell, Ekaterina Zakharova, Gabriel T. Filsinger, Timothy M. Wormier, Jordan P. Hempfling, Lee Chun-Der, Dehua Pei, George M. Church, Charles E. Bell
NUCLEIC ACIDS RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Jian Song, Ziqing Qian, Ashweta Sahni, Kuangyu Chen, Dehua Pei
Review
Pharmacology & Pharmacy
Dehua Pei, George Appiah Kubi
EXPERT OPINION ON DRUG DISCOVERY
(2019)
Article
Computer Science, Artificial Intelligence
Nirav Bhatt, Amit Thakkar
Summary: Stream data is continuously generated data, with real-time processing systems aiming to process data as soon as it arrives. Analysis of stream data requires consideration of related data and data arriving from distributed sources.
PEERJ COMPUTER SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Naman Ruhela, Rohit Bhatia, Ananya Parashar, Pawan Kumar Jaggi, Arti R. Thakkar
Summary: Stem cells are regulated in India, the USA, and the EU with differences in the approval process, time, and fees. India and the USA have similar single registration processes, while the EU has multiple processes. The product approval time is longer in the USA, and the EU charges higher fees compared to other countries.
CURRENT DRUG THERAPY
(2021)
Article
Pharmacology & Pharmacy
Rajender Singh, Swati Singh, Anil Kumar, Giriraj T. Kulkarni, Arti R. Thakkar
Summary: GDUFA II brings more and faster approvals, including increased first-cycle approvals. The legislation also focuses on approving the first generic and complex products, increasing FDA-industry meetings to resolve issues, and reforming the review of drug master files. The GDUFA legislation promotes the availability of generic drugs through increased competition and saves over USD 300 billion annually for the American healthcare system.
ASIAN JOURNAL OF PHARMACEUTICAL RESEARCH AND HEALTH CARE
(2022)
Article
Pharmacology & Pharmacy
Bhumin K. Pathak, Meenakshi Raghav, Arti R. Thakkar, Bhavin A. Vyas, Pranav J. Shah
Summary: The study demonstrated the potential of liquisolid compact technique in enhancing the dissolution rate and bioavailability of Etodolac, leading to improved absorption and efficacy in animal models.
CURRENT DRUG DELIVERY
(2021)
Article
Oncology
Christina Braun, Nadja Schneider, Dehua Pei, Anja Bosserhoff, Silke Kuphal
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
