Journal
ORGANIC LETTERS
Volume 10, Issue 15, Pages 3287-3290Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8011343
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Two reaction sequences commencing with different starting materials were successfully employed for the synthesis of frondosin A analogues, including (+/-)-frondosin A dimethyl ether. Construction of the bicyclo[5.4.0]undecane core in each case was achieved through an expedient microwave-assisted tandem 5-exo cyclization-Claisen rearrangement process.
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