4.8 Article

Copper-catalyzed alkyne-aryne and alkyne-alkene-aryne coupling reactions

Journal

ORGANIC LETTERS
Volume 10, Issue 12, Pages 2393-2396

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol800651h

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The efficient copper-catalyzed two-component coupling reaction of alkynes with arynes and the three-component coupling reaction of alkynes with allylic chlorides and arynes have been developed. Copper acetylide was postulated as a transient intermediate for the initiation of the coupling reactions.

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