Journal
ORGANIC LETTERS
Volume 10, Issue 23, Pages 5425-5428Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol802354u
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Funding
- National Natural Science Foundation of China [20621062]
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The diarylprolinol ether/HOAc-catalyzed Michael addition of aldehydes to gamma-keto-alpha,beta-unsaturated esters occurs in a highly regioselective and enantioselective manner. The adducts could easily be converted into synthetically useful cyclohexenones, cyclohexanones, piperidines, and gamma-lactones.
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