Journal
ORGANIC LETTERS
Volume 10, Issue 5, Pages 815-816Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol7029646
Keywords
-
Categories
Ask authors/readers for more resources
Corey's tamiflu intermediate was synthesized from a bicyclolactam adduct obtained by base-catalyzed Diels-Alder reaction of N-nosyl-3-hydroxy-2-pyridone with ethyl acrylate. A compound that has the same array of functional groups with the Corey's intermediate was obtained in four steps from the DA adduct in 47% overall yield. The intermediate itself was also prepared efficiently by simply changing the protective group.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available