Journal
ORGANIC LETTERS
Volume 10, Issue 22, Pages 5269-5271Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol802065d
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Funding
- NIH [AI 039987]
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A short, flexible synthesis of the marine natural product (2R)-(Z)-dysidazirine (-)-1 has been completed. (-)-1 shows significant antifungal activity across a panel of seven human pathogens, whereas the structural analogue (-)-2, featuring a terminal tert-butyl group, is essentially inactive.
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