Journal
ORGANIC LETTERS
Volume 10, Issue 11, Pages 2307-2310Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8008705
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Funding
- NIGMS NIH HHS [R01 GM064444, R01 GM064444-05, GM-64444] Funding Source: Medline
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Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce Mused heterocycles. The copper reagent plays a double duty in this novel cascade transformation, which proceeds via an S(N)2' substitution followed by a subsequent cycloisomerization step.
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