Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins

Design, Synthesis, and Biological Evaluation of Novel cRGD–Paclitaxel Conjugates for Integrin-Assisted Drug Delivery

(2012) Michael Pilkington-Miksa et al.   BIOCONJUGATE CHEMISTRY

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

(2012) Daniele Lecis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

(2012) Aldo Bianchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer

(2012) X. Wen et al.   CELL PROLIFERATION

Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

(2012) Mattia Marchini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Biological Evaluation (in Vitro and in Vivo) of Cyclic Arginine–Glycine–Aspartate (RGD) Peptidomimetic–Paclitaxel Conjugates Targeting Integrin αVβ3

(2012) Raffaele Colombo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

(2012) John A. Flygare et al.   JOURNAL OF MEDICINAL CHEMISTRY

A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein

(2012) Donatella Potenza et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Integrin Targeted Delivery of Chemotherapeutics

(2012) Kai Chen et al.   Theranostics

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

(2011) Qian Cai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aliskiren

(2010) Sean T. Duggan et al.   DRUGS

Apoptosis in cancer: Key molecular signaling pathways and therapy targets

(2009) Claudia Burz et al.   ACTA ONCOLOGICA

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy

(2009) Pierfausto Seneci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cyclic RGD-Containing Functionalized Azabicycloalkane Peptides as Potent Integrin Antagonists for Tumor Targeting

(2009) Leonardo Manzoni et al.   ChemMedChem

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains

(2007) Zaneta Nikolovska-Coleska et al.   ANALYTICAL BIOCHEMISTRY