4.6 Article

Metal-free aerobic oxidative C-N bond cleavage of tertiary amines for the synthesis of N-heterocycles with high atom efficiency

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 23, Pages 3802-3807

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00578c

Keywords

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Funding

  1. NSFC [U1162109, 21273066, 21172062, 21273067]
  2. Program for Changjiang Scholars and Innovative Research Team in University [IRT1238]
  3. Program for New Century Excellent Talents in Universities [NCET-10-0371]
  4. Fundamental Research Funds for the Central Universities (Hunan University)

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An efficient metal-free aerobic oxidative C-N bond cleavage of tertiary amines has been developed to construct N-heterocycles using molecular oxygen as the sole oxidant with high atom efficiency, in which all of the three alkyl groups in tertiary amines can be utilized and transformed into N-heterocycles.

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