4.6 Article

Copper-catalyzed nucleophilic trifluoromethylation of benzylic chlorides

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 30, Pages 5594-5596

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00957f

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan
  2. Funding Program for Next Generation World-Leading Researchers [GR025]
  3. Grants-in-Aid for Scientific Research [26620075, 26105725, 26105708, 26288044] Funding Source: KAKEN

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Reactions of primary and secondary benzylic chlorides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding benzylic trifluoromethylated products in good to high yields.

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