Article
Biochemistry & Molecular Biology
Poulomi Das, Khac Huy Ngo, Fernaldo Richtia Winnerdy, Arijit Maity, Blaz Bakalar, Yves Mechulam, Emmanuelle Schmitt, Anh Tuan Phan
Summary: This study investigates the adaptability of left-handed G4 structures towards the presence of bulges, presenting the structural characteristics of left-handed G4s accommodating varying numbers of bulges. Bulges in left-handed G4s exhibit distinct features compared to those in right-handed G4s, and elucidation of the intricate structural details may enhance understanding of the potential roles and limitations of these unique structures.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lin Li, Yaping Zhang, Wanzhi Ma, Hui Chen, Mengqin Liu, Ran An, Bingxiao Cheng, Xingguo Liang
Summary: In vivo, left-handed DNA duplex (Z-DNA) is mainly formed in the region of DNA with alternating purine pyrimidine (APP) sequence and plays important biological roles. The study found that under strong topological constraint, non-APP sequences can also form stable left-handed DNA duplex as APP sequences. The thermal stability difference between Z-form and B-form is smaller for APP sequences, which may explain why Z-DNA forms preferentially for APP sequences.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Poulomi Das, Fernaldo Richtia Winnerdy, Arijit Maity, Yves Mechulam, Anh Tuan Phan
Summary: A recent study identified a new motif involved in the formation of left-handed G-quadruplex DNA and determined the X-ray crystal structure of an LHG4 containing this motif. Structural analysis revealed the importance of split guanines and single thymine loops in promoting LHG4 formation.
CHEMICAL COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Reetabrita Roy, Pallab Chakraborty, Arindam Chatterjee, Joy Sarkar
Summary: DNA can adopt various conformations, from right-handed B to left-handed Z; Transition between B-Z DNA is influenced by salt concentration and specific proteins; Z-DNA is associated with certain diseases and large-scale deletions in mammalian cells.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Biophysics
Kevin Li, Liliya A. Yatsunyk, Stephen Neidle
Summary: Left-handed G quadruplexes (LHG4) have been discovered as a new type of G quadruplexes. Our study demonstrates that specific backbone torsion angles can differentiate between right-handed and left-handed G quadruplexes as well as other DNA structures. This analysis provides insights into the conditions of formation for LHG4s and their potential biological relevance.
BIOPHYSICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Joel M. Harp, Leighton Coates, Brendan Sullivan, Martin Egli
Summary: Cryo neutron crystallography was used to investigate the hydrogen bonding patterns of water molecules around a left-handed Z-DNA duplex, revealing orientations of first-shell and second-shell water molecules and uncovering hydration motifs within the minor groove, on the convex surface, and bridging nucleobase and phosphate oxygen atoms. The high-resolution neutron density visualized for the first time pinpointed the orientations of water molecules in contact with the DNA, highlighting unexpected orientations and surprising stabilization effects of exocyclic amino groups of guanine and cytosine. This structure provides the most detailed view to date of DNA solvation in the solid-state unaffected by metal ions or polyamines.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Poulomi Das, Anh Tuan Phan
Summary: This study demonstrates that ligands specific for right-handed G4s do not bind specifically to left-handed G4s, as the presence of tight T-capping in left-handed G4s hinders access to the tetrads.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Isha Dhami, Shivaji A. Thadke, Danith H. Ly
Summary: Gamma peptide nucleic acids (PNAs) are nucleic acid mimics that can bind to DNA or RNA with high affinity and sequence specificity. Researchers have developed a universal monomer system that allows for rapid and selective chemical modification and diversification, expanding the applications of gamma PNAs.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Robotics
Mingxing Cheng, Qingwei Li
Summary: This study focuses on the formation mechanism of helical actuators, discovering that the anisotropic expansion and Young's modulus of the active layer are crucial for helical curling. These key factors may interact or compete with each other, with the dominant factor determining the chirality.
Article
Nanoscience & Nanotechnology
Qiuyu Gao, Ran Wei, Shilin Feng, Chen Chen, Zhenhua Han, Liangbin Chen, Tan Wang, Shaojie Wu, Fushan Li
Summary: This work presents a unique low-cost medium-entropy alloy (MEA) with ultra-high strength and ductility. The MEA exhibits a duplex partially recrystallized microstructure consisting of FCC and BCC phases, along with high density dislocations and nano-precipitates. It shows excellent yield strength and uniform elongation at both room temperature and cryogenic temperatures, as well as a high ultimate tensile strength at 77K. The excellent cryogenic mechanical properties can be attributed to various factors including high density dislocations, ultra-fine grains, nano-precipitates, Luders deformation, hetero-deformation-induced hardening, and deformation-induced martensitic transformation.
SCRIPTA MATERIALIA
(2023)
Article
Engineering, Electrical & Electronic
Jianjia Hu, Pei-Ling Chi, Tao Yang
Summary: This article proposes a novel reconfigurable reflectarray (RRA) with 1 bit beam scanning and switchable linear, left-handed (LH) circular, or right-handed (RH) circular polarization. A 10 x 10 RRA was prototyped with each unit cell using only two p-i-n diodes to implement dual functions. The fabricated RRA can experimentally demonstrate 2-D beam scanning and polarization switching among 45 degrees/135 degrees linear polarization and LH/RH circular polarization.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Chemistry, Multidisciplinary
Fernaldo Richtia Winnerdy, Blaz Bakalar, Poulomi Das, Brahim Heddi, Adrien Marchand, Frederic Rosu, Valerie Gabelica, Anh Tuan Phan
Summary: This study reported the first observation of extremely long-lived K+ and NH4+ ions at the center of a left-handed G-quadruplex DNA. It was found that a single-base mutation could affect this long-lived behavior of the central cation.
Article
Surgery
Madhuri B. Nagaraj, Kareem R. AbdelFattah, Deborah E. Farr
Summary: There is a lack of objective data on the advantages or disadvantages of handedness in surgery. This study analyzed the performance of left-hand and right-hand dominant surgeons on laparoscopic tasks and found significant differences in task completion time. Left-hand dominant surgeons had smaller variability and shorter delta times in task performance.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Karri Sri Naga Sesha, Kenta Yamanaka, Manami Mori, Yusuke Onuki, Shigeo Sato, Damien Fabregue, Akihiko Chiba
Summary: This study demonstrates the combined TRIP/TWIP effect in an alpha + beta titanium alloy by introducing metastable retained beta-phase, enhancing work hardening and uniform elongation.
MATERIALS RESEARCH LETTERS
(2022)
Article
Biotechnology & Applied Microbiology
Lihua Xu, Kaixiang Zhang, Xing Ma, Yingying Li, Yajie Jin, Chenglin Liang, Yong Wang, Wendi Duan, Hongling Zhang, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yunlong Wang, Wentao Li
Summary: This study developed a nanomotor-based cisplatin delivery system that utilizes hydrogen peroxide in tumor tissues to propel the motor for deeper tissue penetration and increased DNA adducts formation. The results showed that this nanomotor has great potential in tumor therapy as it can inhibit tumor growth with minimal side effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yulin Li, Cheng Tian, Zhiyu Liu, Wen Jiang, Chengde Mao
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
Article
Chemistry, Multidisciplinary
Zhiyu Liu, Cheng Tian, Jinwen Yu, Yulin Li, Wen Jiang, Chengde Mao
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Oncology
Yingmei Li, Wenying Pan, Ian D. Connolly, Sunil Reddy, Seema Nagpal, Stephen Quake, Melanie Hayden Gephart
JOURNAL OF NEURO-ONCOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Pengfei Wang, Siyu Wu, Cheng Tian, Guimei Yu, Wen Jiang, Guansong Wang, Chengde Mao
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Chemistry, Multidisciplinary
Ganesh J. Shenoy, David Parobek, Muhammad Salim, Zhiting Li, Cheng Tian, Haitao Liu
Article
Cell Biology
Spyros Darmanis, Steven A. Sloan, Derek Croote, Marco Mignardi, Sophia Chernikova, Peyman Samghababi, Ye Zhang, Norma Neff, Mark Kowarsky, Christine Caneda, Gordon Li, Steven D. Chang, Ian David Connolly, Yingmei Li, Ben A. Barres, Melanie Hayden Gephart, Stephen R. Quake
Article
Chemistry, Multidisciplinary
Julien R. Lhermitte, Aaron Stein, Cheng Tian, Yugang Zhang, Lutz Wiegart, Andrei Fluerasu, Oleg Gang, Kevin G. Yager
Article
Chemistry, Multidisciplinary
Julien R. Lhermitte, Cheng Tian, Aaron Stein, Atikur Rahman, Yugang Zhang, Lutz Wiegart, Andrei Fluerasu, Oleg Gang, Kevin G. Yager
JOURNAL OF APPLIED CRYSTALLOGRAPHY
(2017)
Article
Oncology
Yingmei Li, Boxiang Liu, Ian David Connolly, Bina Wasunga Kakusa, Wenying Pan, Seema Nagpal, Stephen B. Montgomery, Melanie Hayden Gephart
JOURNAL OF THORACIC ONCOLOGY
(2018)
Article
Multidisciplinary Sciences
Mo Li, Mengxi Zheng, Siyu Wu, Cheng Tian, Di Liu, Yossi Weizmann, Wen Jiang, Guansong Wang, Chengde Mao
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Chenhui Hao, Xiang Li, Cheng Tian, Wen Jiang, Guansong Wang, Chengde Mao
NATURE COMMUNICATIONS
(2014)
Article
Multidisciplinary Sciences
Pawel W. Majewski, Aaron Michelson, Marco A. L. Cordeiro, Cheng Tian, Chunli Ma, Kim Kisslinger, Ye Tian, Wenyan Liu, Eric A. Stach, Kevin G. Yager, Oleg Gang
Summary: The rapid development of DNA-based assembly methods allows for the creation of organized nanomaterials with versatile capabilities. By creating inorganic, silica-based replicas of 3D periodic DNA-NP structures, the formed nanomaterials demonstrate excellent resiliency and stability under extreme conditions. This approach opens up new possibilities for the use of DNA assembly strategies in creating organized nanomaterials for a broad range of operational conditions.
Article
Oncology
Yingmei Li, Dina Polyak, Layton Lamsam, Ian David Connolly, Eli Johnson, Lina Khav Khoeur, Stephanie Andersen, Monica Granucci, Geoff Stanley, Boxiang Liu, Seema Nagpal, Melanie Hayden Gephart
Summary: This study utilized single-cell RNA-seq and cell-free RNA analysis to diagnose NSCLC leptomeningeal metastases and found that tumor-associated genes were present in the cerebrospinal fluid. The gene CEACAM6 was identified to play a significant role in NSCLC migration in the brain, which is a hallmark of leptomeningeal metastases.
NPJ PRECISION ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Cheng Tian, Marco Aurelio L. Cordeiro, Julien Lhermitte, Huolin L. Xin, Lior Shani, Mingzhao Liu, Chunli Ma, Yosef Yeshurun, Donald DiMarzio, Oleg Gang
Article
Chemistry, Multidisciplinary
Xiao-Rong Wu, Chen-Wei Wu, Fei Ding, Cheng Tian, Wen Jiang, Cheng-De Mao, Chuan Zhang
CHINESE CHEMICAL LETTERS
(2017)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
