4.6 Article

Copper catalyzed C-O bond formation via oxidative cross-coupling reaction of aldehydes and ethers

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 34, Pages 6549-6553

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00862f

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Funding

  1. National Nature Science Foundation of China [21302013]
  2. Nature Science Foundation of Jiangsu Province [BK2012207]
  3. Nature Science Foundation of Jiangsu Educational Department [12KJA150001, 12KJB150001]

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A practical and efficient construction of C-O bonds via oxidative cross-coupling reaction of aldehydes and ethers has been realized under open air. When 2 mol% copper was used as the catalyst, various alpha-acyloxy ethers were obtained with up to 93% isolated yield.

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