Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000

Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of TH-302, a Hypoxia-Activated Prodrug, in Patients with Advanced Solid Malignancies

(2011) G. J. Weiss et al.   CLINICAL CANCER RESEARCH

The fidelity of spin trapping with DMPO in biological systems

(2011) Kalina Ranguelova et al.   MAGNETIC RESONANCE IN CHEMISTRY

A Phase I Study of the Safety and Pharmacokinetics of the Hypoxia-Activated Prodrug TH-302 in Combination with Doxorubicin in Patients with Advanced Soft Tissue Sarcoma

(2011) Kristen N. Ganjoo et al.   ONCOLOGY

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

(2010) I. M. Pires et al.   CANCER RESEARCH

Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group

(2010) Danny Rischin et al.   JOURNAL OF CLINICAL ONCOLOGY

Critical Impact of Radiotherapy Protocol Compliance and Quality in the Treatment of Advanced Head and Neck Cancer: Results From TROG 02.02

(2010) Lester J. Peters et al.   JOURNAL OF CLINICAL ONCOLOGY

Characterization of Radicals Formed Following Enzymatic Reduction of 3-Substituted Analogues of the Hypoxia-Selective Cytotoxin 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)

(2010) Sujata S. Shinde et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DEPMPO: an efficient tool for the coupled ESR-spin trapping of alkylperoxyl radicals in water

(2010) Hakim Karoui et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Spin Trapping of Radicals Other Than the•OH Radical upon Reduction of the Anticancer Agent Tirapazamine by Cytochrome P450Reductase

(2009) Sujata S. Shinde et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A

(2009) Y. Gu et al.   MOLECULAR CANCER THERAPEUTICS

Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase

(2009) F Peter Guengerich et al.   Nature Protocols

Tricyclic [1,2,4]Triazine 1,4-Dioxides As Hypoxia Selective Cytotoxins

(2008) Michael P. Hay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Initiation of DNA Strand Cleavage by 1,2,4-Benzotriazine 1,4-Dioxide Antitumor Agents: Mechanistic Insight from Studies of 3-Methyl-1,2,4-benzotriazine 1,4-Dioxide

(2008) Venkatraman Junnotula et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY