4.6 Article

MIDA as a simple and highly efficient ligand for palladium-catalyzed Hiyama cross-coupling of aryl halides

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 36, Pages 7136-7139

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01056f

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Funding

  1. National Natural Science Foundation of China [21063015]
  2. Scientific Research Fund of Jiangxi Provincial Education Department [GJJ 12597]

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N-Methyliminodiacetic acid (MIDA) as a simple, air stable and water-soluble ligand has been used in the palladium-catalyzed Hiyama cross-coupling reaction of trimethoxyphenylsilane with aryl halides. The yield of the corresponding Hiyama coupling products is high up to around 90% in water and isopropanol under an ambient atmosphere in the presence of KOH and NaF.

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