Synthesis, kinetic studies and molecular modeling of novel tacrine dimers as cholinesterase inhibitors

Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids

(2012) Ling Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Multitarget-Directed Ligands: Innovative Chemical Probes and Therapeutic Tools Against Alzheimer's Disease

(2011) Maria Laura Bolognesi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers

(2011) Stefano Rizzo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The preparation,in vitroscreening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage

(2011) Kamil Musilek et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Acetylcholinesterase: From 3D structure to function

(2010) Hay Dvir et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities

(2010) Maria Laura Bolognesi et al.   ChemMedChem

Effects of Cholinesterase Inhibitors on the Activities and Protein Levels of Cholinesterases in the Cerebrospinal Fluid of Patients with Alzheimers Disease: A Review of Recent Clinical Studies

(2010) T. Darreh-Shori et al.   Current Alzheimer Research

Hyperbolic mixed-type inhibition of acetylcholinesterase by tetracyclic thienopyrimidines

(2010) C. M. González Tanarro et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Binding or Bending: Distinction of Allosteric Abl Kinase Agonists from Antagonists by an NMR-Based Conformational Assay

(2010) Wolfgang Jahnke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and In Vitro Evaluation of New Tacrine Derivates-Bis-Alkylene Linked 7-MEOTA

(2010) Jan Korabecny et al.   LETTERS IN ORGANIC CHEMISTRY

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds

(2010) Myriam Ouberai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of α-secretase and BACE-1 concurrently

(2009) Hongjun Fu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Solid-Phase Synthesis of Thiazolo[4,5-b]pyridine Derivatives Using Friedländer Reaction

(2009) Taeho Lee et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Why acetylcholinesterase reactivators do not work in butyrylcholinesterase

(2009) Jiří Wiesner et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques

(2009) Paul W. Elsinghorst et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Possible Role of Hydroxylated Metabolites of Tacrine in Drug Toxicity and Therapy of Alzheimers Disease

(2008) Jiri Patocka et al.   CURRENT DRUG METABOLISM

Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors

(2008) Stefania Butini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel anti-Alzheimer’s dimer bis(7)-Cognitin: Cellular and molecular mechanisms of neuroprotection through multiple targets

(2008) Wenming Li et al.   Neurotherapeutics