4.6 Article

A selective fluorescent chemosensor for phosphoserine

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 42, Pages 7387-7392

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41677a

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Funding

  1. National Science Foundation [CHE-1112194]
  2. Division Of Chemistry
  3. Direct For Mathematical & Physical Scien [1112194] Funding Source: National Science Foundation

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A fluorescent chemosensor for the detection of phosphoserine is reported. The ditopic sensor features a phosphate-coordinating zinc(II)-dipicolylamine (Zn2+-DPA) unit tethered to an amine-binding coumarin aldehyde fluorophore. With phosphoserine, the sensor demonstrates a 30-fold fluorescence enhancement under buffered aqueous conditions.

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