Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent

Alkyne Hydrothiolation Catalyzed by a Dichlorobis(aminophosphine) Complex of Palladium: Selective Formation of cis-Configured Vinyl Thioethers

(2012) Roman Gerber et al.   CHEMISTRY-A EUROPEAN JOURNAL

ON 01910.Na Is Selectively Cytotoxic for Chronic Lymphocytic Leukemia Cells through a Dual Mechanism of Action Involving PI3K/AKT Inhibition and Induction of Oxidative Stress

(2012) C. M. Chapman et al.   CLINICAL CANCER RESEARCH

Phase I Study of Rigosertib, an Inhibitor of the Phosphatidylinositol 3-Kinase and Polo-like Kinase 1 Pathways, Combined with Gemcitabine in Patients with Solid Tumors and Pancreatic Cancer

(2012) W. W. Ma et al.   CLINICAL CANCER RESEARCH

Ligand-Controlled Regioselectivity in the Hydrothiolation of Alkynes by Rhodium N-Heterocyclic Carbene Catalysts

(2012) Andrea Di Giuseppe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na

(2012) Matthew J. Olnes et al.   LEUKEMIA RESEARCH

Thiol–yne coupling: revisiting old concepts as a breakthrough for up-to-date applications

(2012) Alessandro Massi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly regio- and stereoselective hydrothiolation of acetylenes with thiols catalyzed by a well-defined supported Rh complex

(2011) Yong Yang et al.   CHEMICAL COMMUNICATIONS

Discovery of a Clinical Stage Multi-Kinase Inhibitor Sodium (E)-2-{2-Methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): Synthesis, Structure–Activity Relationship, and Biological Activity

(2011) M. V. Ramana Reddy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.Na

(2011) Mahesh Seetharam et al.   LEUKEMIA RESEARCH

Organozirconium Complexes as Catalysts for Markovnikov-Selective Intermolecular Hydrothiolation of Terminal Alkynes: Scope and Mechanism

(2010) Charles J. Weiss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction Rates and Mechanisms for Radical, Photoinitated Addition of Thiols to Alkynes, and Implications for Thiol−Yne Photopolymerizations and Click Reactions

(2010) Benjamin D. Fairbanks et al.   MACROMOLECULES

Synthesis of Vinyl Sulfides by Copper-Catalyzed Decarboxylative C−S Cross-Coupling

(2010) Sadananda Ranjit et al.   ORGANIC LETTERS

Water-promoted regioselective hydrothiolation of alkynes

(2009) Sukalyan Bhadra et al.   CANADIAN JOURNAL OF CHEMISTRY

Rhodium(I) and iridium(I) complexes containing bidentate phosphine-imidazolyl donor ligands as catalysts for the hydroamination and hydrothiolation of alkynes

(2009) Leslie D. Field et al.   DALTON TRANSACTIONS

Radical Addition of Ethers to Terminal Alkynes with HighE-Selectivity

(2009) Zili Chen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 2-Aminobenzothiazole via Copper(I)-Catalyzed Tandem Reaction of 2-Iodobenzenamine with Isothiocyanate

(2009) Qiuping Ding et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Phase I Study of ON 01910.Na, a Novel Modulator of the Polo-Like Kinase 1 Pathway, in Adult Patients With Solid Tumors

(2008) Antonio Jimeno et al.   JOURNAL OF CLINICAL ONCOLOGY

A Facile Route to 2,4-Dihydro-1H-benzo[d][1,3]thiazines via Silver-Catalyzed Tandem Addition-Cyclization Reactions

(2008) Qiuping Ding et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Isomerization in Fluorescent Protein Chromophores Involves Addition/Elimination

(2008) Jian Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereo- and Regiospecific Cu-Catalyzed Cross-Coupling Reaction of Vinyl Iodides and Thiols: A Very Mild and General Route for the Synthesis of Vinyl Sulfides

(2008) M. Shahjahan Kabir et al.   ORGANIC LETTERS

Synthesis of 1,1-Disubstituted Olefins via Catalytic Alkyne Hydrothiolation/Kumada Cross-Coupling

(2008) Anthony Sabarre et al.   ORGANIC LETTERS

CuI/L-Proline-Catalyzed Synthesis of Vinyl Sulfides in 95% Alcohol

(2008) Sheng-Rong Guo et al.   SYNTHETIC COMMUNICATIONS

Thiol-mediated radical cyclizations

(2008) Krishna C. Majumdar et al.   TETRAHEDRON

Platinum-Catalyzed Regio- and Stereoselective Arylthiolation of Internal Alkynes

(2007) Fumikazu Yamashita et al.   ORGANIC LETTERS