Concerted, highly asynchronous, enzyme-catalyzed [4 + 2] cycloaddition in the biosynthesis of spinosyn A; computational evidence

JOLTING THE DIELSALDERASE HUNT

(2016) CARMEN DRAHL   CHEMICAL & ENGINEERING NEWS

Biochemistry: Life imitates art

(2011) Wendy L. Kelly   NATURE

Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

(2011) Hak Joong Kim et al.   NATURE

Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-Fluorofarnesyl Diphosphates

(2010) Joseph P. Noel et al.   ACS Chemical Biology

Solanapyrone Synthase, a Possible Diels-Alderase and Iterative Type I Polyketide Synthase Encoded in a Biosynthetic Gene Cluster from Alternaria solani

(2010) Ken Kasahara  et al.   CHEMBIOCHEM

The spinosyn family of insecticides: realizing the potential of natural products research

(2010) Herbert A Kirst   JOURNAL OF ANTIBIOTICS

Compelling Computational Evidence for the Concerted Cyclization of the ABC Rings of Hopene from Protonated Squalene

(2010) Lidia Smentek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Insights on Riboflavin Synthase Inspired by Selective Binding of the 6,7-Dimethyl-8-ribityllumazine Exomethylene Anion

(2010) Ryu-Ryun Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding the mechanism of polar Diels–Alder reactions

(2009) Luis R. Domingo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

(2008) Paul E O'Maille et al.   Nature Chemical Biology