4.6 Article

Domino cyclization-alkylation protocol for the synthesis of 2,3-functionalized indoles from o-alkynylanilines and allylic alcohols

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 19, Pages 3875-3881

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25379h

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Funding

  1. Ministry of Education, Singapore [MOE2009-T2-2-065]
  2. Nanyang Technological University

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A practical and efficient protocol for the one-pot synthesis of 2,3-substituted indoles was developed via a palladacycle catalyzed domino cyclization-alkylation reaction involving 2-alkynylanilines and allylic alcohols under mild conditions without any additives.

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