Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 34, Pages 6834-6839Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26130h
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- National Science Council
- Education of Ministry, Taiwan
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By modifying the conditions from those in Larock's reported synthesis of 3-(2-hydroxyaryl)pyridines from benzynes, and pyridine N-oxides, we altered the regioselectivity of the reaction toward an efficient synthesis of 2-substituted pyridines. The presence of ethyl propiolate altered the regioselectivity to afford 3-substituted pyridine products instead. We conducted appropriate control experiments that enable a full understanding of the mechanism.
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