Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 48, Pages 9601-9619Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26577j
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Funding
- Centre for Cancer Research and Cell Biology at QUB
- National Institutes of Health [DK081367]
- Wayne State University Biology Department Graduate Enhancement grant
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The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
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