Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 43, Pages 8597-8604Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26553b
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Funding
- National Science Foundation
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A direct route to analogs of the naturally occurring tropolone beta-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.
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