Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives

Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate

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Assessing Atropisomer Axial Chirality in Drug Discovery and Development

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DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain

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Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

(2010) Gerhard Bringmann et al.   CHEMICAL REVIEWS

DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype

(2010) Céline Cano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK)

(2010) Céline Cano et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Challenge of Atropisomerism in Drug Discovery

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The DNA-damage response: new molecular insights and new approaches to cancer therapy

(2009) Stephen P. Jackson   BIOCHEMICAL SOCIETY TRANSACTIONS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE