Article
Plant Sciences
Wen-Jing Ren, Chi-Cheng Io, Rong Jiang, Kei-Fong Ng, Jia-Zheng Liu, Li-Ping Bai, Wei Zhang, Zhi-Hong Jiang, Yu-Hong Liu, Guo-Yuan Zhu
Summary: Amethystoidesic acid (1), a triterpenoid with a unique 5/6/6/6 tetracyclic skeleton, and six unknown diterpenoids, amethystoidins A-F (2-7), were isolated from the rhizomes of Isodon amethystoides along with 31 known di-and triterpenoids (8-38). Their structures were determined through comprehensive spectroscopic analysis including 1D and 2D NMR, HRESIMS, and ECD calculations. Compound 1 is the first example of a triterpenoid possessing a rare ring system (5/6/6/6) derived from a contracted A-ring and the 18,19-seco-E-ring of ursolic acid. Compounds 6, 16, 21, 22, 24, and 27 significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, possibly by downregulating LPS-induced iNOS protein expression.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Pingting Li, Lingling Li, Qin Zhu, Mingfeng Xu
Summary: Two new abietane diterpenoids, along with five known diterpenoids, were isolated and characterized from the stems of Clerodendrum bracteatum for the first time. The new compounds showed strong antioxidant activities and cytotoxicity against HL-60 and A549 cell lines.
Article
Biochemistry & Molecular Biology
Yan-Yan Chen, Xiao-Tao Zeng, Ding-Qiao Xu, Shi-Jun Yue, Rui-Jia Fu, Xue Yang, Zhao-Xi Liu, Yu-Ping Tang
Summary: Chemical investigation of the roots of Euphorbia pekinensis Rupr. led to the isolation of five undescribed labdane diterpenoids and two undescribed pimarane diterpenoids, along with nine known diterpenoids. Among these compounds, jolkinol B exhibited strong cytotoxic activity against U-937 and LOVO cancer cell lines.
Article
Biochemistry & Molecular Biology
Cai-Ling Qiu, Zhen-Nan Ye, Bing-Chao Yan, Kun Hu, Jin Yang, Xing-Zhi Yang, Hong-Mei Li, Xiao-Nian Li, Han-Dong Sun, Pema-Tenzin Puno
Summary: Twelve new diterpenoids, together with twenty-eight known ones, have been isolated from the aerial parts of Isodon oresbius. Among them, compound 1 showed cytotoxicity against tumor cells and promoted lysosomal function.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Min Wang, Li-Li Zhong, Xiang-Xiang Fu, Jun Chen
Summary: Two new compounds, isodonserra acid A and B, were isolated from the leaves of Isodon serra. The structures of these compounds were determined through spectroscopic analysis. These compounds exhibited moderate hepatoprotective activity against APAP-induced HepG2 cell injury.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiao-Qiong Zhou, Si-Qi Li, Cai-Ceng Liao, Wei-Feng Dai, Kai-Rui Rao, Xiu-Rong Ma, Rong-Tao Li, Xuan-Qin Chen
Summary: Several novel diterpenoids were isolated from Tripterygium wilfordii, including compounds with rare structures that exhibited significant anti-inflammatory activity. These findings provide valuable insights for the development of novel anti-inflammatory drugs.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Er-Lan Yang, Yong Hou, Guo-Xu Ma, Lin-Jun Zou, Xu-Dong Xu, Hai-Feng Wu, Jun-Shan Yang, Hong-Wan Wei, Cong-Zhao Fan, Zhao-Cui Sun, Lei-Ling Shi
Summary: Eight new compounds were isolated from Nepeta bracteata Benth. and their structures, absolute configurations, and anti-inflammatory activity were investigated. The results showed significant anti-inflammatory activity of these compounds.
FRONTIERS IN CHEMISTRY
(2022)
Article
Plant Sciences
Kadidiatou O. Ndjoubi, Rajan Sharma, Jelili A. Badmus, Ayesha Jacobs, Audrey Jordaan, Jeanine Marnewick, Digby F. Warner, Ahmed A. Hussein
Summary: Plectranthus madagascariensis, a medicinal plant native to South Africa, has shown potential in the treatment of tuberculosis and psoriasis due to its bioactive compounds with antimicrobial and antioxidant properties. The phytochemical studies of this plant led to the isolation of five known royleanone abietanes, which showed promising results in inhibiting Mycobacterium tuberculosis and demonstrating comparable toxicity to tamoxifen against HaCaT cells. The plant is considered an important ethnomedicinal plant and a promising source of diterpenoids for potential therapeutic applications.
Article
Biochemistry & Molecular Biology
Lanlan Nie, Rui Li, Jie Huang, Lingling Wang, Mengjie Ma, Chunyue Huang, Tong Wu, Renjie Yan, Xiao Hu
Summary: Five undescribed abietane diterpenoids, dracocephalumoids A-E, along with six known analogues were isolated from Dracocephalum moldavica. These compounds showed potent suppressive effects against TNF-α, IL-1β, or NO production, with their structure-activity relationship being discussed.
Article
Biochemistry & Molecular Biology
Yun-Fei Wang, Hong-Bin Fang, Yong-Ming Yan, Yong-Xian Cheng
Summary: A series of new and known diterpenoids were isolated from the CH2Cl2 extract of succinum, and their anti-inflammatory potential was evaluated.
Article
Biochemistry & Molecular Biology
Yue Sun, Hong-Ying Yang, Pei-Zhi Huang, Lan-Jun Zhang, Wei-Jiao Feng, Ya Li, Kun Gao
Summary: Nine undescribed abietane diterpenoids (1-9) and eleven known abietane analogs (10-20) were isolated from Callicarpa bodinieri and characterized by various methods. Compounds 3 and 8 exhibited potent anti-inflammatory activities with IC50 values of 36.35 ± 1.12 and 37.21 ± 0.92 μM. The mechanism studies showed that compound 3 inhibited the expression of nitric oxide synthase and p65 involved in the NF-κB pathway.
Article
Biochemistry & Molecular Biology
Long Mu, Tian Li, Peng-Lin Wu, Ling-Qiao Cai, Shu-Ying Li, Zi-Yuan Wang, Yuan-Yuan Liu, Jie Wang, Dong Yan, Zheng-Yun Rao, Chao-Jun Wang, Jian Zhang, Yi Cao, Ke Pan, Zhi-Qi Yin
Summary: Phytochemical investigation of Isodon eriocalyx extract yielded seventeen diterpenoids, including eight previously unreported compounds. Eriocalyxins H-L have unique structural characteristics, with eriocalyxins H-K featuring an unusual 6,11-epoxyspiro-lactone ring and eriocalyxin L featuring a 1,7:3,20-diepoxy-ent kaurene with a 1,7-oxygen linkage. The structures were determined using spectroscopic data interpretation and the absolute configurations confirmed by single-crystal X-ray diffraction. Screening for inhibitory activities against VCAM-1 and ICAM-1 revealed significant inhibitory effects of eriocalyxin O, coetsoidin A, and laxiflorin P against both, and 8(17),13-ent-labdadien-15 -> 16-lactone-19-oic acid exhibited evident inhibitory effect against ICAM-1.
Article
Biochemistry & Molecular Biology
Qin-Feng Zhu, Guo-Bo Xu, Shang-Gao Liao, Xue-Long Yan
Summary: In this study, diterpenoids from the roots of Euphorbia fischeriana were investigated for their cytotoxic effects against cancer cells. Two new diterpenoids were isolated from this plant source and showed significant inhibitory effects against human prostate cancer cells.
Article
Chemistry, Multidisciplinary
Huan Zhao, Yue Liu, Meng Zhang, Guo-dong Chen, Dan Hu, Liang-dong Guo, Zhong-xiang Zhao, Hui Zhi, Hao Gao
Summary: Two new diterpenoids were isolated from Biscogniauxia sp., with their structures elucidated through various analyses. Compound 1 exhibited short-term memory enhancement activity against Alzheimer's disease.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Applied
Hui-Qin Li, Bao-Chen Yang, Madhu Babu Sura, Yong-Xian Cheng, Feng Wang
Summary: In this study, three new diterpenoids were isolated from the resin of Liquidambar formosana Hance, along with five known compounds. The structures of these compounds were determined using spectroscopic and computational methods. Experimental results showed that compounds 1 and 3 exhibited significant anti-inflammatory activities without cytotoxicity. These new diterpenoids have the potential to be candidates for treating inflammation-associated diseases.
NATURAL PRODUCT RESEARCH
(2023)
Review
Medicine, Research & Experimental
Md Abdul Aziz, Md Shahid Sarwar, Tahmina Akter, Md Sahab Uddin, Song Xun, Yu Zhu, Mohammad Safiqul Islam, Zhang Hongjie
Summary: Studies have shown that polyphenolic compounds have preventive and protective effects against cancer, primarily by targeting the STAT3 signaling pathway. These polyphenols exert their effects by inhibiting the activation and phosphorylation of STAT3, thereby blocking cell proliferation, metastasis, and drug resistance.
Article
Medicine, Research & Experimental
Siu Wah Wong-Deyrup, Xun Song, Tsz-Wai Ng, Xiu-Bin Liu, Jian-Guo Zeng, Zhi-Xing Qing, Stephen T. Deyrup, Zhen-Dan He, Hong-Jie Zhang
Summary: The ergosterol pathway is a key target for antifungal drugs, and modifying the MIC assay by adding oxidative stressor or antioxidant allows for screening new drugs that target ergosterol biosynthesis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jia-Nan Zhang, Yi-Xuan Xia, Hong-Jie Zhang
Summary: Natural cyclopeptides have strong anticancer activity and great potential in the development of anticancer agents. They can serve as excellent scaffolds for the synthesis of novel derivatives for combating cancerous pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Organic
Yang Zhao, Chuen-Fai Ku, Xin-Ya Xu, Nga-Yi Tsang, Yu Zhu, Chen-Liang Zhao, Kang-Lun Liu, Chuang-Chuang Li, Lijun Rong, Hong-Jie Zhang
Summary: This study isolated stable arylnaphthalene lignan atropisomers from nature for the first time and found significant differences in antiviral activity between them. The research not only provides important references for the synthesis of novel atropisomers but also offers valuable clues for the development of antiviral drugs.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kang He, Juan Zou, Yu-Xue Wang, Chen-Liang Zhao, Jiang-Hai Ye, Jing-Jie Zhang, Lu-Tai Pan, Hong-Jie Zhang
Summary: A phytochemical investigation of the leaves of Isodon rubescens led to the isolation of two new degraded abietane lactone diterpenoids, rubesanolides F and G. Their structures were elucidated through various spectral analyses, and their biological activities against cancer cells, fungal strains, and bacterial strains were evaluated. These compounds possess unique structural features and exhibit certain biological activities against various organisms.
Review
Plant Sciences
Xin-Ya Xu, Dong-Ying Wang, Yi-Ping Li, Stephen T. Deyrup, Hong-Jie Zhang
Summary: This review systematically evaluates the antiviral activity and mechanisms of action of 630 lignans obtained from medicinal plants and their derivatives. The compounds are classified based on structural characteristics, and details about the most active compounds within each class are discussed. Studies of synthetic lignans that provide structure-activity relationship information are also included in the review.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Nga Yi Tsang, Wan-Fei Li, Elizabeth Varhegyi, Lijun Rong, Hong-Jie Zhang
Summary: This study identified a plant, Maesa perlarius, as an anti-Ebola virus candidate. The stem methanol extract of this plant showed inhibitory effects against Ebola-virus-pseudotyped particles (EBOVpp) and infectious Ebola virus. Further investigation led to the identification of a compound (1) as the most potent inhibitor against pseudovirion-bearing EBOV-GP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Wan-ting Xu, Qiao An, Ling-hui Ruan, Fei Zhou, Lang Zhou, Mei Peng, Li-lang Li, Xiao-sheng Yang, Qi-ji Li, Juan Yang
Summary: This study identified two new indole alkaloids and other compounds from the water extract of sorghum roots, which showed significant inhibition of platelet aggregation. Molecular docking confirmed the binding of these active compounds to P2Y12 and COX-1 receptors in platelets.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiang Yu, Xun Song, Yi Zhang, Yemeng Yang, Jianghai Ye, Yahua Liu, Lutai Pan, Hongjie Zhang
Summary: A series of new derivatives were designed and synthesized based on structure modification of lophanic acid, and their structures were well characterized. The antimicrobial activities of these compounds were evaluated, and it was found that 3d and 3i showed promising inhibitory effects against a wide range of fungi and bacteria.
Article
Biochemistry & Molecular Biology
Faju Chen, Li Wang, Fengli Jin, Liangqun Li, Tao Wang, Ming Gao, Lilang Li, Yu Wang, Zhongsheng Lou, Juan Yang, Qiji Li, Xiaosheng Yang
Summary: The study evaluated the neuroprotective effect of natural compound KF1 against NMDA-induced neurotoxicity, showing that KF1 improved cellular viability, reduced cell apoptosis, enhanced spatial learning memory, regulated neurotransmitters and calcium ion concentration, and decreased NMDAR1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Siva Sundara Kumar Durairajan, Abhay Kumar Singh, Udhaya Bharathy Saravanan, Mayurikaa Namachivayam, Moorthi Radhakrishnan, Jian-Dong Huang, Rahul Dhodapkar, Hongjie Zhang
Summary: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can invade the gastrointestinal system, causing symptoms such as vomiting, diarrhea, and abdominal pain. Understanding the mechanisms of infection and transmission in the gastrointestinal tract is crucial for early detection and targeted therapeutics against COVID-19-induced gastrointestinal infection and inflammatory bowel disease (IBD).
Article
Biochemistry & Molecular Biology
Lang Zhou, Li-shou Yang, Li Wang, Hua-dan Liu, Ming Gao, Fa-ju Chen, Juan Yang, Qi-ji Li, Xiao-sheng Yang
Summary: Three undescribed highly oxidized guaiane-type sesquiterpenes, named cinnamigones A-C, were isolated from the fruits of Cinnamomum migao. Cinnamigone A (1) is structurally similar to artemisinin and exhibits a rare tetracyclic 6/6/7/5 ring system. Compounds 2-3 are classic guaiane sesquiterpenes with different epoxy units. Guaiol (4) is believed to be the precursor of 1-3 in the biosynthetic pathway. The structures and configurations of cinnamigones A-C were determined using spectral analysis, HRESIMS, X-ray crystallography, and ECD calculations. Neuroprotective activity evaluation of 1-3 against N-methyl-D-aspartate (NMDA) toxicity showed that compounds 1-2 exhibited moderate neuroprotective activity.
Article
Nutrition & Dietetics
Chu-Shing Lam, Yi-Xuan Xia, Bai-Sen Chen, Yin-Xiao Du, Kang-Lun Liu, Hong-Jie Zhang
Summary: Management of obesity is crucial for preventing diseases associated with excess body weight such as diabetes. This study investigated the effects of dihydro-resveratrol (DR2) in vitro and in vivo on oxidative stress, adipogenesis, lipogenesis, and insulin sensitivity. The results showed that DR2 can reduce pre-adipocyte maturation, alleviate oxidative stress, reduce lipid accumulation, and promote insulin sensitivity. The therapeutic potential of DR2 for treating obesity and type 2 diabetes was further confirmed in a high-fat diet-induced obesity mouse model.
Article
Chemistry, Organic
Qi-Ji Li, Peng-Fei Tang, Xin Zhou, Wei-Jia Lu, Wen-Jun Xu, Jun Luo, Ling-Yi Kong
Summary: In this study, eight elodeoidins were discovered from Hypericum elodeoides, with elodeoidins 5 and 6 showing significant anti-inflammatory activity. The structures and biosynthetic pathways of these compounds were elucidated, demonstrating the value of the biosynthetic fragment-inspired discovery and elucidation strategy for novel natural products.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Multidisciplinary Sciences
Lihan Zhao, Manali Rupji, Ishita Choudhary, Remus Osan, Shobhna Kapoor, Hong-Jie Zhang, Chunhua Yang, Ritu Aneja
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
