Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 40, Pages 8125-8131Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26334c
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Funding
- National Natural Science Foundation of China [21072020]
- Science and Technology Innovation Program of Beijing Institute of Technology [2011CX01008]
- Development Program for Distinguished Young and Middle-aged Teachers of Beijing Institute of Technology
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An efficient enantioselective Michael addition of 4-hydroxycoumarin to alpha,beta-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).
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