4.6 Article

Asymmetric hydrogenation of alpha- or beta-acyloxy alpha,beta-unsaturated phosphonates catalyzed by a Rh(I) complex of monodentate phosphoramidite

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 8, Pages 1598-1601

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06835k

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Funding

  1. National Natural Science Foundation of China [21172237, 20821002, 21032007]
  2. Major Basic Research Development Program of China [2010CB833300]
  3. Science and Technology Commission of Shanghai Municipality
  4. Chinese Academy of Sciences

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The Rh( I) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of alpha- or beta-acyloxy alpha,beta-unsaturated phosphonates, providing the corresponding biologically important chiral alpha- or beta-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90->99% ee).

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