The stimulating adventure of KRN 7000

Cutting Edge: Nonglycosidic CD1d Lipid Ligands Activate Human and Murine Invariant NKT Cells

(2014) J. D. Silk et al.   JOURNAL OF IMMUNOLOGY

Use of the NEO strategy (Nucleophilic addition/Epoxide Opening) for the synthesis of a new C-galactoside ester analogue of KRN 7000

(2011) Aline Banchet-Cadeddu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation

(2010) Wenlan Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry

(2010) Jeong-Ju Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological activity of α-glucosyl C24:0 and C20:2 ceramides

(2010) Peter J. Jervis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000)

(2010) Masao Shiozaki et al.   CARBOHYDRATE RESEARCH

Attenuation of invariant Natural Killer T-cell anergy induction through intradermal delivery of α-galactosylceramide

(2010) Hetty J. Bontkes et al.   CLINICAL IMMUNOLOGY

Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity

(2010) Ya-Jen Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity

(2010) Vincent Lombardi et al.   JOURNAL OF IMMUNOLOGY

Synthesis and Evaluation of Amino-Modified α-GalCer Analogues

(2010) Matthias Trappeniers et al.   ORGANIC LETTERS

Synthesis of Immunostimulatory α-C-Galactosylceramide Glycolipids via Sonogashira Coupling, Asymmetric Epoxidation, and Trichloroacetimidate-Mediated Epoxide Opening

(2010) Zheng Liu et al.   ORGANIC LETTERS

Asymmetric Synthesis of the α-d-Galactosyl Ceramide KRN7000 via an Organocatalytic Aldol Reaction as Key Step

(2010) Dieter Enders et al.   SYNTHESIS-STUTTGART

RCAI-37, 56, 59, 60, 92, 101, and 102, cyclitol and carbasugar analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines☆

(2009) Takuya Tashiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide

(2009) Natacha Veerapen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH

(2009) Geetha Velmourougane et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of 3″- and 4″-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000

(2009) Ravinder Raju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aminocyclitol-Substituted Phytoceramides and their Effects on iNKT Cell Stimulation

(2009) Youssef Harrak et al.   ChemMedChem

Nonglycosidic Agonists of Invariant NKT Cells for Use as Vaccine Adjuvants

(2009) B. Gopal Reddy et al.   ChemMedChem

The Synthesis and in vivo Evaluation of 2′,2′-Difluoro KRN7000

(2009) Leo Leung et al.   ChemMedChem

Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation

(2009) Jin S. Im et al.   IMMUNITY

Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells

(2009) Xiangming Li et al.   IMMUNOLOGY

Computational Structure Activity Relationship Studies on the CD1d/Glycolipid/TCR Complex Using AMBER and AUTODOCK

(2009) Janos Nadas et al.   Journal of Chemical Information and Modeling

Invariant TCR Rather Than CD1d Shapes the Preferential Activities of C-Glycoside Analogues Against Human Versus Murine Invariant NKT Cells

(2009) X. Li et al.   JOURNAL OF IMMUNOLOGY

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells

(2009) Barbara A. Sullivan et al.   JOURNAL OF IMMUNOLOGY

A Phase I-II Study of  -Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer

(2009) S. Motohashi et al.   JOURNAL OF IMMUNOLOGY

Focus on the Controversial Activation of Human iNKT Cells by 4-Deoxy Analogue of KRN7000

(2009) Vivien Lacône et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of threitol ceramide and [14C]threitol ceramide, non-glycosidic analogues of the potent CD1d antigen α-galactosyl ceramide

(2009) Yoel R. Garcia Diaz et al.   TETRAHEDRON-ASYMMETRY

Structural and Functional Aspects of Lipid Binding by CD1 Molecules

(2008) Jonathan D. Silk et al.   Annual Review of Cell and Developmental Biology

Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties

(2008) Yang Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand

(2008) Jeong-Ju Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

α-S-GalCer: Synthesis and evaluation for iNKT cell stimulation

(2008) Marisa L. Blauvelt et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro Evaluation of α‐GalCer Epimers

(2008) Matthias Trappeniers et al.   ChemMedChem

Direct and Efficient Glycosylation Protocol for Synthesizing α-Glycolipids: Application to the Synthesis of KRN7000

(2008) Omar Boutureira et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants

(2008) Sungjune Kim et al.   Expert Review of Vaccines

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR

(2008) Kwok S. Wun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synthesis of α-Galactosyl Ceramide (KRN7000) and Analogues Thereof via a Common Precursor and Their Preliminary Biological Assessment

(2008) Mario Michieletti et al.   JOURNAL OF ORGANIC CHEMISTRY

6′-Derivatised α-GalCer Analogues Capable of Inducing Strong CD1d-Mediated Th1-Biased NKT Cell Responses in Mice

(2008) Matthias Trappeniers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Microarray Analysis of Intact Glycolipid−CD1d Interaction and Correlation with Cell-Based Cytokine Production

(2008) Pi-Hui Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

(2008) Leo Leung et al.   ORGANIC LETTERS

The First Synthesis of a Thioglycoside Analogue of the Immunostimulant KRN7000

(2008) Ravindra T. Dere et al.   ORGANIC LETTERS

An Efficient and General Enantioselective Synthesis of Sphingosine, Phythosphingosine, and 4-Substituted Derivatives†

(2008) Josep Llaveria et al.   ORGANIC LETTERS

C-Galactosylceramide diastereomers via Sharpless asymmetric epoxidation chemistry

(2008) Jun Pu et al.   TETRAHEDRON

Molecular dynamics simulation study on the interaction of KRN 7000 and three analogues with human CD1d

(2008) Eric Hénon et al.   TETRAHEDRON

RCAI-61, the 6′-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-γ in vivo

(2008) Takuya Tashiro et al.   TETRAHEDRON LETTERS

Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, α-galactosylceramide

(2008) Yaoxing Huang et al.   VACCINE

Glycolipids as immunostimulating agents

(2007) Douglass Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

RCAI-8, 9, 18, 19, and 49–52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines

(2007) Ken-ichi Fuhshuku et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hypothesized role of galactocerebroside and NKT cells in the etiology of multiple sclerosis

(2007) Megan M. Blewett   MEDICAL HYPOTHESES

Highly efficient and stereoselective synthesis of β-glycolipids

(2007) José Antonio Morales-Serna et al.   ORGANIC & BIOMOLECULAR CHEMISTRY