Article
Chemistry, Multidisciplinary
Tomohiro Fujimoto, Yuta Ueda, Hideki Sugimoto, Jun Nakazawa, Shiro Hikichi, Shinobu Itoh
Summary: The selective oxidation of cyclohexane to cyclohexyl hydroperoxide and its subsequent conversion to cyclohexanol have been studied using osmium tetroxide as the catalyst. The addition of a coordinative anion enhances the catalytic reactivity of osmium tetroxide. Furthermore, an immobilized acid catalyst has been successfully developed.
Article
Chemistry, Multidisciplinary
Joshua D. Tibbetts, William B. Cunningham, Massimiliano Vezzoli, Pawel Plucinski, Steven D. Bull
Summary: The solvent-free continuous flow epoxidation of a range of biorenewable terpene substrates using a recyclable tungsten-based polyoxometalate phase transfer catalyst and aqueous H2O2 as an oxidant enables efficient and safe production of epoxides in commercial microreactors. These procedures are applicable for the safe production of multigram quantities of a wide range of epoxides from trisubstituted and disubstituted alkenes.
Article
Chemistry, Inorganic & Nuclear
Roberta Colaiezzi, Andrea Lazzarini, Francesco Ferella, Valentina Paolucci, Andrea Di Giuseppe, Marcello Crucianelli
Summary: Three novel active and stable magnetic nanocatalysts were prepared for the selective oxidation of olefins. These heterogeneous systems showed excellent catalytic performance in both organic and aqueous solvents, with the ability to be recycled and reused over five runs without significant decrease in activity. The good magnetic properties of these catalytic systems demonstrate their versatility and robustness.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Organic
Xiaoxue Li, Hangzhou Hua, Yonghong Liu, Lei Yu
Summary: Catalyzed by Se/Fe via hybrid mechanisms, the carbon-carbon double bond in alkenes can break to produce carbonyls under mild conditions. Using O-2 as a partial oxidant, the amount of H2O2 employed can be reduced (90 mol% vs 250 mol%) to avoid peroxide residues, making the process safer for operation.
Article
Chemistry, Multidisciplinary
Dan E. Wise, Emma S. Gogarnoiu, Alana D. Duke, Joshua M. Paolillo, Taylor L. Vacala, Waseem A. Hussain, Marvin Parasram
Summary: We report a new method for anaerobic cleavage of alkenes into carbonyl compounds using nitroarenes as oxygen transfer reagents under visible light. This approach is a safe and practical alternative to traditional oxidative cleavage methods. Mechanistic studies show that the transformation occurs through direct photoexcitation of the nitroarene followed by nonstereospecific radical cycloaddition with alkenes. Various alkenes with oxidatively sensitive functionalities can be efficiently and selectively cleaved anaerobically to generate carbonyl derivatives.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Qiangwen Fan, Honglei Zhang, Dawei Liu, Chunpei Yan, Haibo Zhu, Zongbo Xie, Zhanggao Le
Summary: Here, we reported a facile and accessible visible-light-driven photocatalytic protocol for the oxidative cleavage of C C bonds to form carbonyl compounds using CsPbBr3 nanocrystals as photocatalysts. This catalytic system is applicable to a wide range of terminal and internal alkenes. Mechanism studies revealed that a single-electron transfer process involving the superoxide radical (O-2 (& BULL;-)) and photogenerated holes played a crucial role in this transformation. DFT calculations showed that the reaction started with the addition of O-2 (& BULL;-) to the terminal carbon atom of the C C bond and proceeded to release one molecule of formaldehyde through the formation of a [2 + 2] intermediate; the latter step being the rate-determining process.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Engineering, Chemical
Min Lei, Qian Gao, Kemeng Zhou, Parikshit Gogoi, Jing Liu, Jiabao Wang, Hainong Song, Shuangfei Wang, Xinliang Liu
Summary: A catalytic system using PMA and H2O2 was developed for degrading 4-CP, resulting in complete conversion of 4-CP into other AOX and CO2/H2O, with PMA promoting free radical formation and showing exceptional efficiency in 4-CP degradation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Engineering, Environmental
Zaiyong Yang, Zengxi Wei, Shunxin Zhou, Bo Bao, Shuangliang Zhao, Fuzhong Gong
Summary: This study reports a new continuous DSHP process by constructing a feasible microreactor upon microfluidic chip under ambient condition, which achieved continuous production of H2O2 with high concentration. The study provides a promising on-site route to produce H2O2 in a green, safe yet ready-to-use process.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Organic
Jinhua Ou, Saiyu He, Wei Wang, Hong Tan, Kaijian Liu
Summary: This method involves the oxidative cleavage of olefins to carbonyls using 1,4-dioxane as a promoter, achieving up to 95% conversion. It is simple, catalyst-free, and suitable for large-scale synthesis without the need for external additives.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Kristina Jajcevic, Ashlin Mario Sequeira, Jana Kalbacova, Dietrich R. T. Zahn, Kaori Sugihara
Summary: A 40 nm wide carbon nanoribbons was fabricated based on fixation and pyrolysis of an organic template, lipid nanotubes, which achieved the smallest feature size through pyrolysis of surface-patterned organic templates. This pyrolytic carbon nanostructure shows potential for future electronics and sensing applications.
Article
Chemistry, Organic
Marc Paul Beller, Sergei Ivlev, Ulrich Koert
Summary: A stereoselective synthesis method for the proposed and actual structures of natural products preussochromones E and F is reported. The key step involves a ring-closing metathesis reaction to form a five-membered ring and install the trans configuration of the annulated five-six membered ring system. Analysis of the (3)J NMR couplings between the isolated natural product and the synthesized compound revealed the cis annulation in its real structure, which can also be synthesized using an intramolecular aldol reaction.
Article
Chemistry, Multidisciplinary
Takahiro Watanabe, Kyohei Oga, Hiroaki Matoba, Masanori Nagatomo, Masayuki Inoue
Summary: In this study, we report a concise synthesis of Taxol. By designing the carbon and oxygen rings and utilizing radical reactions and catalytic cyclization, we successfully achieved the total synthesis of Taxol. This provides valuable information for designing and executing syntheses of other oxygenated terpenoids with high density.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Tshepo Molefe, Dean Barrett, Beatriz Diaz, Roy Forbes, Neil J. Coville
Summary: This study reports on the synthesis and application of osmium nanoparticles supported on and/or encapsulated in hollow carbon spheres for Fischer-Tropsch Synthesis (FTS). It is demonstrated that the interaction between osmium and cobalt has a significant effect on the catalyst activity when loaded together. Proximity of osmium and cobalt leads to higher FTS activity and C5+ production through the primary spillover effect. This study reveals the effect of osmium on FTS catalysts for the first time.
JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Qibin Chen, Guanyin Yuan, Tao Yuan, Huiting Zeng, Zheng-Rong Zou, Zong-cai Tu, Jie Gao, Yi Zou
Summary: Cytochrome P450s are versatile oxidases that catalyze important chemical transformations in the biosynthesis of natural products. We discovered a group of P450s that can reshape the cycloaraneosene framework to form a sordarinane architecture. One of these enzymes, SdnB, cleaves the C-C bond of the epoxy residue to yield formyl groups, while SdnF selectively oxidizes one of the formyl groups to a carboxyl group and accelerates the final cyclization reaction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Juliano M. Fernandes, Rafael N. Soek, Thalita C. do Nascimento, Leociley R. A. Menezes, Guilherme L. Sassaki, Renan B. Campos
Summary: This study investigates the degradation of organophosphate pesticides promoted by 1,2,4-triazole through kinetic studies, NMR analyses, and theoretical calculations. The results show that TAZ(-) enhances the degradation of OPs in alkaline conditions, with potential for the design of novel catalysts.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)